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Tdark
PPP1R3E
Protein phosphatase 1 regulatory subunit 3E

Protein Summary
Description
Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000452015
  • ENSP00000408288
  • ENSG00000235194
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.57
histone modification site profile
0.54
transcription factor perturbation
0.54
cellular component
0.52
transcription factor binding site profile
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 8   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.33   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 8   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
PPP1R3F
Tbio
Family:  Enzyme
Novelty:  0.06150915
Score:  0.948
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.922
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.869
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.855
Data Source:  STRINGDB
PPP1R3A
Tbio
Family:  Enzyme
Novelty:  0.03534333
Score:  0.853
Data Source:  STRINGDB
PPP1R3B
Tbio
Family:  Enzyme
Novelty:  0.0244434
Score:  0.844
Data Source:  STRINGDB
PPP1R3C
Tbio
Family:  Enzyme
Novelty:  0.01784199
Score:  0.839
Data Source:  STRINGDB
PPP1R3D
Tdark
Family:  Enzyme
Novelty:  0.53609018
Score:  0.825
Data Source:  STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
Score:  0.771
Data Source:  STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
Score:  0.712
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
95.1
BMI-adjusted hip circumference
2
7
8
87.7
electrocardiography
2
1
61
5.3
83.4
heart rate
2
1
1
5.3
83.3
reticulocyte measurement
3
3
3
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
95.1
BMI-adjusted hip circumference
8
87.7
electrocardiography
61
5.3
83.4
heart rate
1
5.3
83.3
reticulocyte measurement
3
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3E
VGNC:12581
452795
Macaque
protein phosphatase 1 regulatory subunit 3E
713209
Mouse
MGI:2145790
105651
Rat
RGD:1583926
691447
Dog
protein phosphatase 1 regulatory subunit 3E
VGNC:44900
490610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3E
Macaque
protein phosphatase 1 regulatory subunit 3E
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 3E
Publication Statistics
PubMed Score 0.33
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title