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Tbio
TDRD3
Tudor domain-containing protein 3

Protein Summary
Description
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000196169
  • ENSP00000196169
  • ENSG00000083544
  • ENST00000377881
  • ENSP00000367113
  • ENST00000377894
  • ENSP00000367126
  • ENST00000535286
  • ENSP00000440190
  • ENST00000621840
  • ENSP00000477993
  • ENST00000648252
  • ENSP00000498191
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
transcription factor perturbation
0.84
virus perturbation
0.76
transcription factor
0.67
cell line
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
1
2
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
79
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (90)
1 – 10 of 90
TOP3B
Tbio
Family: Enzyme
Novelty: 0.06607389
Score: 0.99
Data Source: STRINGDB
FXR1
Tbio
Novelty: 0.01279428
Score: 0.906
Data Source: STRINGDB
FMR1
Tbio
Family: Epigenetic
Novelty: 0.00032203
Score: 0.9
Data Source: STRINGDB
FXR2
Tbio
Family: Epigenetic
Novelty: 0.0253623
Score: 0.896
Data Source: STRINGDB
TDRD1
Tbio
Family: Epigenetic
Novelty: 0.04645566
Score: 0.753
Data Source: STRINGDB
TOP3A
Tbio
Family: Enzyme
Novelty: 0.0055546
Score: 0.75
Data Source: STRINGDB
SUSD1
Tdark
Novelty: 0.54249826
Score: 0.721
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.721
Data Source: STRINGDB
TDRD7
Tbio
Family: Epigenetic
Novelty: 0.03580848
Score: 0.716
Data Source: STRINGDB
SLC46A2
Tdark
Family: Transporter
Novelty: 0.12003352
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.88

PubMed score by year
PubTator Score  6.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer