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Tbio
WDR26
WD repeat-containing protein 26

Protein Summary
Description
G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (PubMed:29911972). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from ox ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414423
  • ENSP00000408108
  • ENSG00000162923

Symbol
  • CDW2
  • MIP2
  • CDW2
  • GID7
  • MIP2
  • SKDEAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
disease perturbation
0.93
microRNA
0.86
virus perturbation
0.83
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.5   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.5   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
88.6
leukocyte count
2
2
2
87.7
myeloid white cell count
1
1
1
78.9
apolipoprotein A 1 measurement
2
2
2
63
reticulocyte measurement
2
1
2
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
88.6
leukocyte count
2
87.7
myeloid white cell count
1
78.9
apolipoprotein A 1 measurement
2
63
reticulocyte measurement
2
62.1
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:21208]
Macaque
WD repeat domain 26
704911
Mouse
MGI:1923825
226757
Rat
RGD:1565589
498301
Dog
WD repeat domain 26
VGNC:48358
480115
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:21208]
Macaque
WD repeat domain 26
Mouse
Rat
Dog
WD repeat domain 26
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H7D7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (77)
1 – 10 of 77
GCG
Tchem
Novelty:  0.00004879
p_int:  0.999670849
p_ni:  0.000329152
Data Source:  BioPlex
RMND5A
Tbio
Novelty:  0.01820349
p_int:  0.999405391
p_ni:  0.000594609
Score:  0.984
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.998056873
p_ni:  0.001943127
Data Source:  BioPlex
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.997158247
p_ni:  0.002841753
Data Source:  BioPlex
INSL6
Tdark
Novelty:  0.06986187
p_int:  0.994312671
p_ni:  0.005687329
Score:  0.195
Data Source:  BioPlex,STRINGDB
SPON1
Tbio
Novelty:  0.01071398
p_int:  0.993255618
p_ni:  0.006744383
Data Source:  BioPlex
PRICKLE3
Tbio
Novelty:  0.26347141
p_int:  0.988834463
p_ni:  0.011165537
Data Source:  BioPlex
MRPL4
Tdark
Novelty:  0.27290276
p_int:  0.988789719
p_ni:  0.011210281
Score:  0.177
Data Source:  BioPlex,STRINGDB
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
p_int:  0.982235842
p_ni:  0.017764159
Data Source:  BioPlex
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.980221023
p_ni:  0.019778977
Score:  0.211
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.50

PubMed score by year
PubTator Score  10.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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