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Tbio
SYNC
Syncoilin

Protein Summary
Description
Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins. This gene encodes a member of the intermediate filament family which contains an N-terminal head domain, followed by a central coiled-coil region and a short C-terminal tail. The protein is highly expressed in skeletal and cardiac muscle. The protein links the dystrophin associated protein complex (DAPC) to desmin filaments in muscle and may have a structural role in striated muscle. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373484
  • ENSP00000362583
  • ENSG00000162520
  • ENST00000409190
  • ENSP00000386439

Symbol
  • SYNC1
  • SYNC1
  • SYNCOILIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
histone modification site profile
0.82
tissue sample
0.73
microRNA
0.64
PubMedID
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.2
body mass index
1
1
1
59
visceral adipose tissue measurement
1
1
1
33.1
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.2
body mass index
1
59
visceral adipose tissue measurement
1
33.1
1
2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syncoilin, intermediate filament protein
VGNC:10957
456720
Mouse
MGI:1916078
68828
Rat
RGD:1307970
362606
Dog
syncoilin, intermediate filament protein
VGNC:49861
487303
Horse
syncoilin, intermediate filament protein
VGNC:50770
100070162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syncoilin, intermediate filament protein
Mouse
Rat
Dog
syncoilin, intermediate filament protein
Horse
syncoilin, intermediate filament protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H7C4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (68)
1 – 10 of 68
PRPH
Tbio
Novelty:  0.25890973
p_int:  1
Score:  0.166
Data Source:  BioPlex,STRINGDB
DES
Tbio
Novelty:  0.00651741
p_int:  0.999999942
p_ni:  9e-9
p_wrong:  4.8e-8
Score:  0.718
Data Source:  BioPlex,STRINGDB
CCDC136
Tbio
Novelty:  0.09279967
p_int:  0.999999877
p_ni:  1.2e-7
p_wrong:  3e-9
Data Source:  BioPlex
TJAP1
Tbio
Novelty:  0.008967
p_int:  0.999999865
p_ni:  1.35e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.999998469
p_ni:  0.00000153
Data Source:  BioPlex
APC
Tchem
Novelty:  0.00168376
p_int:  0.999998436
p_ni:  0.000001564
Data Source:  BioPlex
CEP55
Tbio
Novelty:  0.01328073
p_int:  0.999997913
p_ni:  0.000002087
Data Source:  BioPlex
INA
Tbio
Novelty:  0.00708581
p_int:  0.999993008
p_ni:  0.000006992
Score:  0.311
Data Source:  BioPlex,STRINGDB
SYNM
Tbio
Novelty:  0.01167838
p_int:  0.999991051
p_ni:  0.000008947
p_wrong:  2e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
NEFM
Tbio
Novelty:  0.00239134
p_int:  0.999985282
p_ni:  0.000014718
Score:  0.667
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  25.44

PubMed score by year
PubTator Score  12.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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