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Tchem
SMYD3
Histone-lysine N-methyltransferase SMYD3

Protein Summary
Description
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000490107
  • ENSP00000419184
  • ENSG00000185420
  • ENST00000630181
  • ENSP00000487434

Symbol
  • ZMYND1
  • ZNFN3A1
  • KMT3E
  • ZMYND1
  • ZNFN3A1
  • bA74P14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.97
biological process
0.94
virus perturbation
0.88
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.51   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.51   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (19)
1 – 10 of 19
CHEMBL3798468
chemical structure image
CHEMBL3798741
chemical structure image
CHEMBL3798006
chemical structure image
CHEMBL3798012
chemical structure image
CHEMBL3797575
chemical structure image
CHEMBL3798134
chemical structure image
CHEMBL3797708
chemical structure image
CHEMBL3797949
chemical structure image
CHEMBL3798404
chemical structure image
CHEMBL3799643
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
37.4
Cognitive impairment
1
1
0
1.5
36.2
electrocardiography
1
1
3
20.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
37.4
Cognitive impairment
0
1.5
36.2
electrocardiography
3
20.5
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (104)
1 – 10 of 104
HSP90AB3P
Tdark
p_int: 0.999999829
p_ni: 1.7e-7
p_wrong: 1e-9
Data Source: BioPlex
HSP90AB4P
Tdark
p_int: 0.999999635
p_ni: 3.65e-7
Data Source: BioPlex
HSP90AA5P
Tdark
p_int: 0.999975728
p_ni: 0.000024251
p_wrong: 2e-8
Data Source: BioPlex
RCAN3
Tbio
Novelty: 0.12819457
p_int: 0.9960711
p_ni: 0.003548159
p_wrong: 0.000380741
Score: 0.207
Data Source: BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty: 0.00016774
p_int: 0.994797126
p_ni: 0.005202874
Score: 0.709
Data Source: BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
p_int: 0.991392809
p_ni: 0.008607191
Score: 0.486
Data Source: BioPlex,STRINGDB
KDM3B
Tbio
Family: Epigenetic
Novelty: 0.05322289
p_int: 0.958719081
p_ni: 0.041009623
p_wrong: 0.000271295
Score: 0.617
Data Source: BioPlex,STRINGDB
MAP3K2
Tchem
Family: Kinase
Novelty: 0.01201472
Score: 0.939
Data Source: STRINGDB
HELZ
Tbio
Family: Enzyme
Novelty: 0.08786982
Score: 0.879
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.51

PubMed score by year
PubTator Score  64.63

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer