SMYD3
Histone-lysine N-methyltransferase SMYD3
Protein Summary
Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation (PubMed:15235609, PubMed:22419068). Also methylates 'Lys-5' of histone H4 (PubMed:22419068). Plays an important role in transcriptional activation as a member of an RNA polymerase complex (PubMed:15235609). Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences (PubMed:15235609). This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000490107
- ENSP00000419184
- ENSG00000185420
- ENST00000630181
- ENSP00000487434
- ZMYND1
- ZNFN3A1
- KMT3E
- ZMYND1
- ZNFN3A1
- bA74P14.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
trait | 0.97 | ||
biological process | 0.94 | ||
virus perturbation | 0.88 | ||
transcription factor binding site profile | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 143.32 (req: < 5)
Gene RIFs: 94 (req: <= 3)
Antibodies: 251 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 143.32 (req: >= 5)
Gene RIFs: 94 (req: > 3)
Antibodies: 251 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 79
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0