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Tbio
CPLANE1
Ciliogenesis and planar polarity effector 1

Protein Summary
Description
Involved in ciliogenesis (PubMed:25877302). Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies (By similarity). The protein encoded by this gene has putative coiled-coil domains and may be a transmembrane protein. Defects in this gene are a cause of Joubert syndrome (JBTS). [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425232
  • ENSP00000389014
  • ENSG00000197603
  • ENST00000508244
  • ENSP00000421690

Symbol
  • C5orf42
  • JBTS17
  • Hug
  • OFD6
  • JBTS17
  • C5orf42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.7   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 31   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.7   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 31   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
NUP155
Tbio
Novelty:  0.03884486
Score:  0.905
Data Source:  STRINGDB
WDR70
Tdark
Novelty:  0.37521871
Score:  0.905
Data Source:  STRINGDB
NIPBL
Tbio
Novelty:  0.00462654
Score:  0.756
Data Source:  STRINGDB
TMEM231
Tbio
Novelty:  0.17100188
Score:  0.749
Data Source:  STRINGDB
TMEM216
Tbio
Novelty:  0.07870718
Score:  0.736
Data Source:  STRINGDB
TCTN3
Tdark
Novelty:  0.24504659
Score:  0.702
Data Source:  STRINGDB
DDX59
Tbio
Family:  Enzyme
Novelty:  0.21349779
Score:  0.686
Data Source:  STRINGDB
TMEM67
Tbio
Novelty:  0.02573267
Score:  0.685
Data Source:  STRINGDB
CEP41
Tbio
Novelty:  0.29561674
Score:  0.684
Data Source:  STRINGDB
TMEM138
Tdark
Novelty:  0.40357932
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Genes related to primary cilium development (based on CRISPR)
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Genes related to primary cilium development (based on CRISPR)
Joubert Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
3
3
71.9
body height
2
2
2
67.9
1
1
1
53.3
diet measurement
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
71.9
body height
2
67.9
1
53.3
diet measurement
1
1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ciliogenesis and planar polarity effector 1
VGNC:3918
461916
Macaque
chromosome 6 open reading frame, human C5orf42
701698
Mouse
MGI:1920942
73692
Rat
RGD:1310081
310137
Pig
chromosome 16 C5orf42 homolog
100516883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ciliogenesis and planar polarity effector 1
Macaque
chromosome 6 open reading frame, human C5orf42
Mouse
Rat
Pig
chromosome 16 C5orf42 homolog
Publication Statistics
PubMed Score 41.70
PubMed score by year
PubTator Score 153.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title