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Tdark
TMEM134
Transmembrane protein 134

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308022
  • ENSP00000312615
  • ENSG00000172663
  • ENST00000393877
  • ENSP00000377455
  • ENST00000545682
  • ENSP00000438439
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
kinase perturbation
0.76
cell type or tissue
0.7
disease perturbation
0.68
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.47   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.47   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
40.1
mean reticulocyte volume
1
1
1
6.8
apolipoprotein A 1 measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
40.1
mean reticulocyte volume
1
6.8
apolipoprotein A 1 measurement
1
1.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 134
VGNC:979
745834
Macaque
transmembrane protein 134
711894
Rat
RGD:1305824
361695
Dog
transmembrane protein 134
VGNC:47472
610471
Horse
transmembrane protein 134
VGNC:24196
100147448
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 134
Macaque
transmembrane protein 134
Rat
Dog
transmembrane protein 134
Horse
transmembrane protein 134
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H6X4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (19)
1 – 10 of 19
IP6K1
Tbio
Family: Kinase
Novelty: 0.03418032
p_int: 0.99999999
p_ni: 9e-9
Data Source: BioPlex
UBXN4
Tdark
Novelty: 0.16206743
p_int: 0.999999988
p_ni: 1.1e-8
Data Source: BioPlex
UBE4A
Tbio
Novelty: 0.02576018
p_int: 0.999999858
p_ni: 1.41e-7
p_wrong: 2e-9
Data Source: BioPlex
USP20
Tbio
Family: Enzyme
Novelty: 0.06647037
p_int: 0.999590199
p_ni: 0.000144035
p_wrong: 0.000265766
Data Source: BioPlex
USP33
Tbio
Family: Enzyme
Novelty: 0.04411285
p_int: 0.966258052
p_ni: 0.033741912
p_wrong: 3.6e-8
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.814514107
p_ni: 0.185485893
Data Source: BioPlex
TMEM183A
Tdark
Novelty: 0.4017284
Score: 0.522
Data Source: STRINGDB
TMEM14B
Tbio
Novelty: 0.98487964
Score: 0.473
Data Source: STRINGDB
ZDHHC12
Tdark
Family: Enzyme
Novelty: 0.34034594
Score: 0.473
Data Source: STRINGDB
VPS13C
Tbio
Novelty: 0.05207291
Score: 0.464
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.47

PubMed score by year
PubTator Score  2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer