Tbio ANTXR1 Anthrax toxin receptor 1

Protein Summary

Description

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• Q9H6X2
• A8K7U8
• J7K7G4
• J7KF88
• Q4ZFV6
• Q53QD8
• Q96P02
• Q9NVP3

Gene Name

• ANTXR1

Ensembl ID

• ENST00000303714
• ENSP00000301945
• ENSG00000169604
• ENST00000409349
• ENSP00000386494
• ENST00000409829
• ENSP00000387058

Symbol

• ATR
• TEM8
• ATR
• GAPO
• TEM8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
transcription factor perturbation	0.88
PubMedID	0.84
ligand (protein) perturbation	0.83
kinase perturbation	0.81

Protein Classes

PANTHER Classes

Protein / Receptor / Anthrax Toxin Receptor 1

DTO Classes

Protein / Receptor / Anthrax Toxin Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.31   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 569   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.31   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 569   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0