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Tbio
BCAS3
Breast carcinoma-amplified sequence 3

Protein Summary
Description
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390652
  • ENSP00000375067
  • ENSG00000141376
  • ENST00000407086
  • ENSP00000385323
  • ENST00000408905
  • ENSP00000386173
  • ENST00000588462
  • ENSP00000468592
  • ENST00000588874
  • ENSP00000464825
  • ENST00000589222
  • ENSP00000466078

Symbol
  • MAAB
  • GAOB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
trait
0.93
histone modification site profile
0.89
transcription factor binding site profile
0.85
phenotype
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.19   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.19   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.999995956
p_ni:  0.000004044
Score:  0.824
Data Source:  BioPlex,STRINGDB
WIPI2
Tbio
Novelty:  0.02685992
p_int:  0.999994267
p_ni:  0.000005733
Score:  0.876
Data Source:  BioPlex,STRINGDB
MAGEE1
Tbio
Novelty:  0.10759081
p_int:  0.998533292
p_ni:  0.001466708
Score:  0.71
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.901568961
p_ni:  0.098431039
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.888387086
p_ni:  0.111612914
Score:  0.151
Data Source:  BioPlex,STRINGDB
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.810913489
p_ni:  0.189086402
p_wrong:  1.09e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.779306834
p_ni:  0.220693166
Score:  0.177
Data Source:  BioPlex,STRINGDB
BCAS4
Tbio
Novelty:  0.11759439
Score:  0.906
Data Source:  STRINGDB
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.902
Data Source:  STRINGDB
ANKS1A
Tbio
Novelty:  0.01972212
Score:  0.692
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (56)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
11
15
24
14.9
99.5
creatinine measurement
7
14
18
99.5
heel bone mineral density
3
15
18
99.4
BMI-adjusted waist circumference
7
12
20
95.6
hemoglobin measurement
3
3
4
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
24
14.9
99.5
creatinine measurement
18
99.5
heel bone mineral density
18
99.4
BMI-adjusted waist circumference
20
95.6
hemoglobin measurement
4
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCAS3, microtubule associated cell migration factor
VGNC:12032
454802
Macaque
BCAS3, microtubule associated cell migration factor
712846
Mouse
MGI:2385848
192197
Dog
BCAS3, microtubule associated cell migration factor
VGNC:38400
480587
Horse
BCAS3, microtubule associated cell migration factor
VGNC:51379
100071315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCAS3, microtubule associated cell migration factor
Macaque
BCAS3, microtubule associated cell migration factor
Mouse
Dog
BCAS3, microtubule associated cell migration factor
Horse
BCAS3, microtubule associated cell migration factor
Publication Statistics
PubMed Score 25.19
PubMed score by year
PubTator Score 14.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title