Tbio RPAP3 RNA polymerase II-associated protein 3

Protein Summary

Description

Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. This gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9H6T3
• B4DRW9
• Q6PHR5

Gene Name

• RPAP3

Ensembl ID

• ENST00000005386
• ENSP00000005386
• ENSG00000005175
• ENST00000380650
• ENSP00000370024
• ENST00000432584
• ENSP00000401823

Symbol

• Tah1
• hSpagh

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.8
histone modification site profile	0.74
protein domain	0.73
disease perturbation	0.68
tissue sample	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.98   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 144   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.98   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0