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Tbio
ESRP2
Epithelial splicing regulatory protein 2

Protein Summary
Description
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000473183
  • ENSP00000418748
  • ENSG00000103067
  • ENST00000565858
  • ENSP00000454554

Symbol
  • RBM35B
  • RBM35B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
virus perturbation
0.83
transcription factor perturbation
0.8
PubMedID
0.67
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.96   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
3
91.8
glomerular filtration rate
4
3
3
6.4
77.8
high density lipoprotein cholesterol measurement
1
1
1
73.7
metabolite measurement
1
1
1
70.5
apolipoprotein A 1 measurement
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
91.8
glomerular filtration rate
3
6.4
77.8
high density lipoprotein cholesterol measurement
1
73.7
metabolite measurement
1
70.5
apolipoprotein A 1 measurement
1
67.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epithelial splicing regulatory protein 2
VGNC:5759
454187
Macaque
epithelial splicing regulatory protein 2
702287
Mouse
MGI:1924661
77411
Rat
RGD:1310855
307810
Dog
epithelial splicing regulatory protein 2
VGNC:40479
489745
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epithelial splicing regulatory protein 2
Macaque
epithelial splicing regulatory protein 2
Mouse
Rat
Dog
epithelial splicing regulatory protein 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H6T0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (67)
1 – 10 of 67
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.999929453
p_ni:  1.76e-7
p_wrong:  0.000070371
Score:  0.522
Data Source:  BioPlex,STRINGDB
RBFOX2
Tbio
Novelty:  0.00856339
Score:  0.968
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.939
Data Source:  STRINGDB
ESRP1
Tbio
Novelty:  0.02035464
Score:  0.928
Data Source:  STRINGDB
TIA1
Tbio
Novelty:  0.00264338
Score:  0.928
Data Source:  STRINGDB
TIAL1
Tbio
Novelty:  0.01126806
Score:  0.928
Data Source:  STRINGDB
HNRNPH1
Tbio
Novelty:  0.01273351
Score:  0.916
Data Source:  STRINGDB
HNRNPF
Tbio
Novelty:  0.01833966
Score:  0.912
Data Source:  STRINGDB
POLR2K
Tbio
Family:  Enzyme
Novelty:  0.06121272
Score:  0.904
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.903
Data Source:  STRINGDB
Publication Statistics
PubMed Score  20.96

PubMed score by year
PubTator Score  11.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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