AZI2
5-azacytidine-induced protein 2
Protein Summary
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]
- ENST00000334100
- ENSP00000335609
- ENSG00000163512
- ENST00000420543
- ENSP00000391696
- ENST00000457172
- ENSP00000389577
- ENST00000479665
- ENSP00000419371
- NAP1
- TBKBP2
- AZ2
- NAP1
- TILP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
virus perturbation | 1 | ||
transcription factor binding site profile | 0.91 | ||
kinase perturbation | 0.84 | ||
interacting protein | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.61 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 109 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.61 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 109 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (32)
BBOX1
Family: Enzyme
Novelty: 0.00255489
p_int: 0.999999707
p_ni: 2.93e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
APBA3
Novelty: 0.05059532
p_int: 0.999999434
p_ni: 5.64e-7
p_wrong: 2e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
CALCOCO2
Novelty: 0.01456844
p_int: 0.999998792
p_ni: 3.2e-8
p_wrong: 0.000001176
Score: 0.706
Data Source: BioPlex,STRINGDB
IRAK3
Family: Kinase
Novelty: 0.01001206
p_int: 0.987415372
p_ni: 0.000576863
p_wrong: 0.012007764
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (31)
KEGG (1)
WikiPathways (30)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | RIG-I-like receptor signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
RIG-I-like receptor signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (1)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 5 | 5 | 5 | 96 | |||||
lymphocyte percentage of leukocytes | 2 | 2 | 2 | 89.6 | |||||
red blood cell distribution width | 1 | 1 | 1 | 45.7 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 35 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 5 | 96 | |||||
lymphocyte percentage of leukocytes | 2 | 89.6 | |||||
red blood cell distribution width | 1 | 45.7 | |||||
monocyte percentage of leukocytes | 1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | 5-azacytidine induced 2 | VGNC:5034 | 460239 | |||||
Macaque | 5-azacytidine induced 2 | 705275 | ||||||
Mouse | MGI:1351332 | 27215 | ||||||
Rat | RGD:1310530 | 316051 | ||||||
Dog | 5-azacytidine induced 2 | VGNC:38328 | 485632 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | 5-azacytidine induced 2 | |||||
Macaque | 5-azacytidine induced 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | 5-azacytidine induced 2 | |||||
Publication Statistics
PubMed Score 5.61
PubMed score by year
PubTator Score 7.54
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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