Tbio AZI2 5-azacytidine-induced protein 2

Protein Summary

Description

Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1. AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H6S1
• A8K3M2
• C9JB40
• H7BXU6
• Q86W99
• Q9BQF1

Gene Name

• AZI2

Ensembl ID

• ENST00000334100
• ENSP00000335609
• ENSG00000163512
• ENST00000420543
• ENSP00000391696
• ENST00000457172
• ENSP00000389577
• ENST00000479665
• ENSP00000419371

Symbol

• NAP1
• TBKBP2
• AZ2
• NAP1
• TILP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
virus perturbation	1
transcription factor binding site profile	0.91
kinase perturbation	0.84
interacting protein	0.81

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.54   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (31)

KEGG (1)

WikiPathways (30)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	RIG-I-like receptor signaling pathway	69 targets	path:hsa04622

Name	Explore in Pharos	Explore in Source
RIG-I-like receptor signaling pathway	69 targets	path:hsa04622

Gene Ontology Terms (11)

Components (1)

Processes (10)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
cytoplasm	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

BBOX1

Tchem

Family: Enzyme

Novelty: 0.00263045

p_int: 0.999999707

p_ni: 2.93e-7

Score: 0.237

Data Source: BioPlex,STRINGDB

APBA3

Tbio

Novelty: 0.06087545

p_int: 0.999999434

p_ni: 5.64e-7

p_wrong: 2e-9

Score: 0.189

Data Source: BioPlex,STRINGDB

CALCOCO2

Tbio

Novelty: 0.00398884

p_int: 0.999998792

p_ni: 3.2e-8

p_wrong: 0.000001176

Score: 0.706

Data Source: BioPlex,STRINGDB

PIP

Tbio

Novelty: 0.00268794

p_int: 0.999998601

p_ni: 0.000001398

Data Source: BioPlex

IRAK3

Tchem

Family: Kinase

Novelty: 0.01432197

p_int: 0.987415372

p_ni: 0.000576863

p_wrong: 0.012007764

Score: 0.189

Data Source: BioPlex,STRINGDB

TBK1

Tchem

Family: Kinase

Novelty: 0.00150228

Score: 0.999

Data Source: STRINGDB

IKBKE

Tchem

Family: Kinase

Novelty: 0.01836892

Score: 0.945

Data Source: STRINGDB

TANK

Tbio

Novelty: 0.01379942

Score: 0.906

Data Source: STRINGDB

TBKBP1

Tbio

Family: Enzyme

Novelty: 0.18771585

Score: 0.901

Data Source: STRINGDB

IKBKG

Tbio

Family: Kinase

Novelty: 0.00081998

Score: 0.85

Data Source: STRINGDB

Publication Statistics

PubMed Score  3.54

PubMed score by year

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PubTator Score  7.54

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLE

1-70

EKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRT

70-140

EVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQ

140-210

KLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTA

210-280

TYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWV

280-350

FPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN

350-392

MDALVEDDICILNHEKAHKRDTVTPVSIYSGDESVASHFALVTAYEDIKKRLKDSEKENSLLKKRIRFLEEKLIARFEEETSSVGREQVNKAYHAYREVCIDRDNLKSKLDKMNKDNSESLKVLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSNWEVEKLSCDLKIHGLEQELELMRKECSDLKIELQKAKQTDPYQEDNLKSRDLQKLSISSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSTAIKKACAPVGCSEDLGRDSTKLHLMNFTATYTRHPPLLPNGKALCHTTSSPLPGDVKVLSEKAILQSWTDNERSIPNDGTCFQEHSSYGRNSLEDNSWVFPSPPKSSETAFGETKTKTLPLPNLPPLHYLDQHNQNCLYKN

Find similar targets by:

Uniprot Keyword

3D-structure
Alternative splicing
Coiled coil
Complete proteome
Cytoplasm
Host-virus interaction
Phosphoprotein
Reference proteome