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Tbio
YTHDC2
3'-5' RNA helicase YTHDC2

Protein Summary
Description
3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity). This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000161863
  • ENSP00000161863
  • ENSG00000047188

Symbol
  • CAHL
  • hYTHDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
interacting protein
0.97
histone modification site profile
0.72
cell line
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.49   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 23   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.49   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (242)
1 – 10 of 242
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.999968415
p_ni:  0.000031585
Score:  0.151
Data Source:  BioPlex,STRINGDB
TNNT3
Tbio
Novelty:  0.0212335
p_int:  0.99805709
p_ni:  0.00194291
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.994958846
p_ni:  0.005041154
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.980177576
p_ni:  0.019822424
Data Source:  BioPlex
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.979866465
p_ni:  0.020133535
Data Source:  BioPlex
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.970969048
p_ni:  0.029030952
Data Source:  BioPlex
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.963919965
p_ni:  0.036080035
Data Source:  BioPlex
NOP53
Tbio
Novelty:  0.00353077
p_int:  0.962271204
p_ni:  0.037728796
Score:  0.303
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.953828957
p_ni:  0.046171043
Score:  0.157
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.889669504
p_ni:  0.110330496
Data Source:  BioPlex
Gene Ontology Terms (18)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
AgBase
Inferred from Physical Interaction (IPI)
AgBase
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lip morphology measurement
1
1
1
39.6
body mass index
1
1
1
24.5
BMI-adjusted waist-hip ratio
1
1
1
15.8
1
1
1
14.2
BMI-adjusted waist circumference
1
1
1
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lip morphology measurement
1
39.6
body mass index
1
24.5
BMI-adjusted waist-hip ratio
1
15.8
1
14.2
BMI-adjusted waist circumference
1
5.7
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
YTH domain containing 2
VGNC:4228
462004
Macaque
YTH domain containing 2
694612
Mouse
MGI:2448561
240255
Rat
RGD:1563192
307446
Dog
YTH domain containing 2
VGNC:48504
474641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
YTH domain containing 2
Macaque
YTH domain containing 2
Mouse
Rat
Dog
YTH domain containing 2
Publication Statistics
PubMed Score 29.49
PubMed score by year
PubTator Score 5.64
PubTator score by year