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Tbio
ZDHHC6
Palmitoyltransferase ZDHHC6

Protein Summary
Description
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369404
  • ENSP00000358412
  • ENSG00000023041
  • ENST00000369405
  • ENSP00000358413

Symbol
  • ZNF376
  • DHHC-6
  • ZNF376
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
histone modification site profile
0.91
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
virus perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (45)
1 – 10 of 45
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999995232
p_ni:  0.000004755
p_wrong:  1.3e-8
Data Source:  BioPlex
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.999989809
p_ni:  0.00001019
p_wrong:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.999988842
p_ni:  0.000011158
Data Source:  BioPlex
CD226
Tbio
Novelty:  0.00374102
p_int:  0.99994964
p_ni:  0.00005036
Data Source:  BioPlex
PLVAP
Tbio
Novelty:  0.01230117
p_int:  0.999931778
p_ni:  0.000068222
Score:  0.234
Data Source:  BioPlex,STRINGDB
BTC
Tbio
Novelty:  0.00673076
p_int:  0.99983558
p_ni:  0.000139048
p_wrong:  0.000025372
Score:  0.281
Data Source:  BioPlex,STRINGDB
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.999825475
p_ni:  0.000174516
p_wrong:  9e-9
Data Source:  BioPlex
CLDN17
Tbio
Novelty:  0.23348754
p_int:  0.999630951
p_ni:  0.000345874
p_wrong:  0.000023175
Data Source:  BioPlex
LRTM2
Tdark
Novelty:  1.14285986
p_int:  0.999610645
p_ni:  0.000389262
p_wrong:  9.3e-8
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.999561231
p_ni:  0.000438768
p_wrong:  2e-9
Score:  0.263
Data Source:  BioPlex,STRINGDB
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
6
97.1
mathematical ability
4
2
4
78.2
6
4
0
1.1
77.5
triglyceride measurement
2
2
2
53.7
1
1
0
1.1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
97.1
mathematical ability
4
78.2
0
1.1
77.5
triglyceride measurement
2
53.7
0
1.1
52.7
Find similar targets by:
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 6
VGNC:7868
450740
Macaque
zinc finger DHHC-type containing 6
696538
Mouse
MGI:1914230
66980
Rat
RGD:1304657
361771
Dog
zinc finger DHHC-type containing 6
VGNC:48592
477821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger DHHC-type containing 6
Macaque
zinc finger DHHC-type containing 6
Mouse
Rat
Dog
zinc finger DHHC-type containing 6
Publication Statistics
PubMed Score 5.42
PubMed score by year
PubTator Score 4.33
PubTator score by year