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Tbio
ACSS3
Acyl-CoA synthetase short-chain family member 3, mitochondrial

Protein Classes
Protein Summary
Description
Activates acetate so that it can be used for lipid synthesis or for energy generation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000548058
  • ENSP00000449535
  • ENSG00000111058
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
trait
0.86
cell line
0.69
pathway
0.6
histone modification site profile
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.43   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.43   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
5
3
5
64.3
alcohol use disorder measurement
1
1
1
46.1
gait measurement
1
1
1
40.7
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
5
64.3
alcohol use disorder measurement
1
46.1
gait measurement
1
40.7
1
31.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 3
VGNC:12755
452099
Macaque
acyl-CoA synthetase short chain family member 3
697823
Mouse
MGI:2685720
380660
Rat
RGD:1307051
314800
Dog
acyl-CoA synthetase short chain family member 3
VGNC:54190
475414
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase short chain family member 3
Macaque
acyl-CoA synthetase short chain family member 3
Mouse
Rat
Dog
acyl-CoA synthetase short chain family member 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H6R3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Ketone body metabolism (R-HSA-74182)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ketone body metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of Ketone Bodies
Name
Explore in Pharos
Explore in Source
Ketone body metabolism
Metabolism
Metabolism of lipids
Synthesis of Ketone Bodies
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (60)
1 – 10 of 60
PCCA
Tbio
Family:  Enzyme
Novelty:  0.00515417
Score:  0.942
Data Source:  STRINGDB
PCCB
Tbio
Family:  Enzyme
Novelty:  0.01085161
Score:  0.93
Data Source:  STRINGDB
ALDH3A2
Tbio
Family:  Enzyme
Novelty:  0.0059198
Score:  0.929
Data Source:  STRINGDB
ALDH2
Tclin
Family:  Enzyme
Novelty:  0.00077122
Score:  0.927
Data Source:  STRINGDB
ACSS1
Tbio
Family:  Enzyme
Novelty:  0.02003886
Score:  0.921
Data Source:  STRINGDB
ACSS2
Tchem
Family:  Enzyme
Novelty:  0.00448879
Score:  0.918
Data Source:  STRINGDB
ALDH6A1
Tbio
Family:  Enzyme
Novelty:  0.03785268
Score:  0.916
Data Source:  STRINGDB
ECHDC1
Tbio
Family:  Enzyme
Novelty:  0.02711265
Score:  0.91
Data Source:  STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
Score:  0.909
Data Source:  STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.906
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.43

PubMed score by year
PubTator Score  1.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer