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Tbio
SLA2
Src-like-adapter 2

Protein Summary
Description
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262866
  • ENSP00000262866
  • ENSG00000101082
  • ENST00000360672
  • ENSP00000353890

Symbol
  • C20orf156
  • SLAP2
  • MARS
  • SLAP2
  • SLAP-2
  • C20orf156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.73
tissue sample
0.7
cell type or tissue
0.67
cellular component
0.63
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 375   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 375   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
1
1
86.8
gut microbiome measurement
1
1
1
43.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
86.8
gut microbiome measurement
1
43.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Src like adaptor 2
VGNC:14296
735438
Macaque
Src like adaptor 2
702574
Mouse
MGI:1925049
77799
Rat
RGD:1562071
499931
Dog
Src like adaptor 2
VGNC:46203
485859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Src like adaptor 2
Macaque
Src like adaptor 2
Mouse
Rat
Dog
Src like adaptor 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H6Q3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Interleukin signaling pathway
PathwayCommons: pid
TCR signaling in naïve CD4+ T cells
PathwayCommons: netpath
TCR
PathwayCommons: netpath
BCR
Name
Explore in Pharos
Explore in Source
Interleukin signaling pathway
TCR signaling in naïve CD4+ T cells
TCR
BCR
Protein-Protein Interactions (58)
1 – 10 of 58
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.965
Data Source: STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.0011564
Score: 0.958
Data Source: STRINGDB
CD247
Tbio
Novelty: 0.00217194
Score: 0.946
Data Source: STRINGDB
CD3G
Tclin
Novelty: 0.00466154
Score: 0.921
Data Source: STRINGDB
CD3D
Tclin
Novelty: 0.00510314
Score: 0.917
Data Source: STRINGDB
CD3E
Tclin
Novelty: 0.0053855
Score: 0.906
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.906
Data Source: STRINGDB
HLA-DRA
Tbio
Novelty: 0.0060214
Score: 0.902
Data Source: STRINGDB
HLA-DRB1
Tchem
Novelty: 0.00240724
Score: 0.9
Data Source: STRINGDB
HLA-DRB1
Tbio
Novelty: 0.00240724
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  88.10

PubMed score by year
PubTator Score  24.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer