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Tchem
TASP1
Threonine aspartase 1

Protein Summary
Description
Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster. This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337743
  • ENSP00000338624
  • ENSG00000089123

Symbol
  • C20orf13
  • C20orf13
  • dJ585I14.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.76
transcription factor perturbation
0.74
transcription factor binding site profile
0.68
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.34   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
yzm18
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
1
1
0
1.1
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
0
1.1
45
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taspase 1
VGNC:14306
735437
Macaque
taspase 1
694028
Mouse
MGI:1923062
75812
Rat
RGD:1308591
311468
Dog
taspase 1
VGNC:47122
477152
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taspase 1
Macaque
taspase 1
Mouse
Rat
Dog
taspase 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H6P5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (29)
1 – 10 of 29
ASPG
Tbio
Family: Enzyme
Novelty: 0.00338263
Score: 0.835
Data Source: STRINGDB
KMT2A
Tchem
Family: Epigenetic
Novelty: 0.00192554
Score: 0.779
Data Source: STRINGDB
ZBTB34
Tdark
Family: TF
Novelty: 0.5693361
Score: 0.704
Data Source: STRINGDB
GTF2A1
Tchem
Novelty: 0.19577296
Score: 0.681
Data Source: STRINGDB
KMT2B
Tbio
Family: Epigenetic
Novelty: 0.00593529
Score: 0.668
Data Source: STRINGDB
POLR1B
Tbio
Family: Enzyme
Novelty: 0.06955307
Score: 0.663
Data Source: STRINGDB
GZF1
Tbio
Family: TF
Novelty: 0.15337347
Score: 0.613
Data Source: STRINGDB
HCFC1
Tbio
Novelty: 0.00440762
Score: 0.593
Data Source: STRINGDB
THOC1
Tbio
Novelty: 0.03702557
Score: 0.59
Data Source: STRINGDB
NPM1
Tbio
Novelty: 0.0005485
Score: 0.587
Data Source: STRINGDB
Publication Statistics
PubMed Score  39.34

PubMed score by year
PubTator Score  22.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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