Tbio TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase

Protein Summary

Description

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q9H6E5
• A1A527
• A8K995
• Q2NL65
• Q7L583
• Q9H6H7
• Star-PAP

Gene Name

• TUT1

Ensembl ID

• ENST00000476907
• ENSP00000419607
• ENSG00000149016

Symbol

• RBM21
• PAPD2
• RBM21
• TENT1
• URLC6
• TUTase
• STARPAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
transcription factor binding site profile	0.97
kinase perturbation	0.95
cell type or tissue	0.77
transcription factor	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Speckle Targeted Pip5k1a-regulated Poly(a) Polymerase

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Speckle Targeted Pip5k1a-regulated Poly(a) Polymerase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.65   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.65   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0