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Tdark
ASB7
Ankyrin repeat and SOCS box protein 7

Protein Summary
Description
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contains a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. In this way, SOCS box containing proteins may regulate protein turnover by targeting proteins for polyubiquination and, therefore, for proteasome-mediated degradation. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332783
  • ENSP00000328327
  • ENSG00000183475
  • ENST00000343276
  • ENSP00000339819
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
histone modification site profile
0.82
microRNA
0.77
cell type or tissue
0.65
transcription factor binding site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.91   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
1
1
90.6
cup-to-disc ratio measurement
4
3
5
84.3
optic cup area measurement
3
3
3
64.5
balding measurement
1
1
1
4.7
chin morphology measurement
1
1
0
1.1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
90.6
cup-to-disc ratio measurement
5
84.3
optic cup area measurement
3
64.5
balding measurement
1
4.7
chin morphology measurement
0
1.1
4.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 7
VGNC:11822
467845
Macaque
ankyrin repeat and SOCS box containing 7
693956
Mouse
MGI:2152835
117589
Rat
RGD:1305154
365277
Dog
ankyrin repeat and SOCS box containing 7
VGNC:38167
488707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat and SOCS box containing 7
Macaque
ankyrin repeat and SOCS box containing 7
Mouse
Rat
Dog
ankyrin repeat and SOCS box containing 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H672-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (368)
1 – 10 of 368
C8orf34
Tdark
Novelty: 0.25922336
p_int: 1
Score: 0.381
Data Source: BioPlex,STRINGDB
OGN
Tbio
Novelty: 0.00097407
p_int: 0.999999999
p_ni: 1e-9
Score: 0.234
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.999999992
p_ni: 8e-9
Score: 0.955
Data Source: BioPlex,STRINGDB
TRIP11
Tbio
Novelty: 0.03011344
p_int: 0.999999892
p_ni: 1.08e-7
Score: 0.192
Data Source: BioPlex,STRINGDB
CUL5
Tbio
Novelty: 0.00792494
p_int: 0.999999818
p_ni: 1.82e-7
Score: 0.958
Data Source: BioPlex,STRINGDB
NPAT
Tbio
Novelty: 0.01063979
p_int: 0.999999811
p_ni: 1.89e-7
Data Source: BioPlex
CEP170
Tbio
Novelty: 0.05342931
p_int: 0.999999157
p_ni: 8.4e-7
p_wrong: 4e-9
Data Source: BioPlex
ADAM33
Tchem
Family: Enzyme
Novelty: 0.00584097
p_int: 0.999998841
p_ni: 0.000001159
Data Source: BioPlex
AGRP
Tbio
Novelty: 0.00147804
p_int: 0.999998091
p_ni: 0.000001909
Data Source: BioPlex
HMBOX1
Tbio
Family: TF
Novelty: 0.02455652
p_int: 0.999996221
p_ni: 0.000003778
p_wrong: 1e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4.91

PubMed score by year
PubTator Score  1.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer