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Tbio
STN1
CST complex subunit STN1

Protein Summary
Description
Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation (PubMed:19854130). However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST complex inhibits telomerase and is involved in telomere length homeostasis; it is proposed to bind to newly telomerase-synthesized 3' overhangs and to terminate telomerase action implicating the association with the ACD:POT1 complex thus interfering with its telomerase stimulation activity. The CST complex is also proposed to be involved in fill-in synthesis of the telomeric C-strand probably implicating recruitment ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224950
  • ENSP00000224950
  • ENSG00000107960
  • ENST00000369764
  • ENSP00000358779

Symbol
  • OBFC1
  • AAF44
  • OBFC1
  • AAF-44
  • RPA-32
  • bA541N10.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.76   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.76   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (183)
TEN1
Tbio
Novelty:  0.02194283
p_int:  0.999999992
p_ni:  8e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
CTC1
Tbio
Novelty:  0.01298038
p_int:  0.999999215
p_ni:  7.85e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
ORC3
Tbio
Novelty:  0.03409802
p_int:  0.999998749
p_ni:  9.21e-7
p_wrong:  3.3e-7
Score:  0.377
Data Source:  BioPlex,STRINGDB
ORC2
Tbio
Novelty:  0.11963517
p_int:  0.999995832
p_ni:  0.000004101
p_wrong:  6.7e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
GMNN
Tbio
Novelty:  0.00436572
p_int:  0.999989292
p_ni:  0.000010708
Score:  0.417
Data Source:  BioPlex,STRINGDB
ACTR3C
Tdark
Novelty:  0.16443513
p_int:  0.999962544
p_ni:  0.000018788
p_wrong:  0.000018668
Score:  0.236
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999931937
p_ni:  0.000068063
Data Source:  BioPlex
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
p_int:  0.999636805
p_ni:  0.000362226
p_wrong:  9.69e-7
Data Source:  BioPlex
SMC5
Tbio
Novelty:  0.008623
p_int:  0.999493135
p_ni:  0.000506863
p_wrong:  2e-9
Score:  0.633
Data Source:  BioPlex,STRINGDB
SMC6
Tbio
Novelty:  0.02450073
p_int:  0.999279554
p_ni:  0.000720446
Score:  0.618
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Lung fibrosis
WikiPathways
Development of pulmonary dendritic cells and macrophage subsets
Name
Explore in Pharos
Explore in Source
Lung fibrosis
Lung fibrosis
Lung fibrosis
Lung fibrosis
Development of pulmonary dendritic cells and macrophage subsets
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
6
5
6
92.7
3
3
1
1.1
87.5
mean corpuscular volume
3
3
3
86.8
4
3
0
1.2
79.3
mean reticulocyte volume
1
1
1
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
telomere length
6
92.7
1
1.1
87.5
mean corpuscular volume
3
86.8
0
1.2
79.3
mean reticulocyte volume
1
74.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
STN1, CST complex subunit
VGNC:9749
450715
Macaque
STN1, CST complex subunit
714968
Mouse
MGI:1915581
108689
Rat
RGD:1305637
294025
Dog
STN1, CST complex subunit
VGNC:46930
477812
Species
Name
OMA
EggNOG
Inparanoid
Chimp
STN1, CST complex subunit
Macaque
STN1, CST complex subunit
Mouse
Rat
Dog
STN1, CST complex subunit
Publication Statistics
PubMed Score 69.76
PubMed score by year
PubTator Score 31.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title