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Tbio
RPP21
Ribonuclease P protein subunit p21

Protein Summary
Description
Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376642
  • ENSP00000365829
  • ENSG00000239927
  • ENST00000411784
  • ENSP00000412619
  • ENSG00000241863
  • ENST00000414187
  • ENSP00000398396
  • ENSG00000243009
  • ENST00000415583
  • ENSP00000403747
  • ENST00000416977
  • ENSP00000404312
  • ENSG00000241779
  • ENST00000424616
  • ENSP00000399295
  • ENST00000425575
  • ENSP00000405834
  • ENST00000428040
  • ENSP00000394320
  • ENSG00000241370
  • ENST00000430900
  • ENSP00000415046
  • ENST00000433076
  • ENSP00000409799
  • ENST00000434282
  • ENSP00000414284
  • ENSG00000242726
  • ENST00000435318
  • ENSP00000411003
  • ENSG00000239865
  • ENST00000436442
  • ENSP00000397778
  • ENST00000437470
  • ENSP00000408610
  • ENST00000442966
  • ENSP00000403833
  • ENST00000455025
  • ENSP00000409193

Symbol
  • C6orf135
  • CAT60
  • CAT60
  • C6orf135
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
tissue sample
0.62
molecular function
0.56
disease
0.53
tissue
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.22   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.22   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (189)
Items per page:
1 – 5 of 189
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
Items per page:
1 – 5 of 189
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914926
67676
Rat
RGD:1303090
406230
Dog
ribonuclease P/MRP subunit p21
VGNC:54354
474824
Opossum
ribonuclease P/MRP subunit p21
103103048
Anole lizard
ribonuclease P/MRP subunit p21
100561750
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ribonuclease P/MRP subunit p21
Opossum
ribonuclease P/MRP subunit p21
Anole lizard
ribonuclease P/MRP subunit p21
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H633-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (140)
1 – 10 of 140
RPP25L
Tdark
Family:  Enzyme
Novelty:  1.39761189
p_int:  0.999997627
p_ni:  0.000002372
p_wrong:  1e-9
Score:  0.857
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999996909
p_ni:  0.000003091
Score:  0.997
Data Source:  BioPlex,STRINGDB
RPP40
Tbio
Family:  Enzyme
Novelty:  0.05981624
p_int:  0.99999623
p_ni:  0.00000377
Score:  0.997
Data Source:  BioPlex,STRINGDB
POP7
Tbio
Family:  Enzyme
Novelty:  0.05460002
p_int:  0.999973609
p_ni:  0.000026383
p_wrong:  8e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
RPP14
Tbio
Family:  Enzyme
Novelty:  0.10813341
p_int:  0.999970786
p_ni:  0.000009761
p_wrong:  0.000019454
Score:  0.997
Data Source:  BioPlex,STRINGDB
POP4
Tbio
Family:  Enzyme
Novelty:  0.01072287
p_int:  0.999970504
p_ni:  0.000029398
p_wrong:  9.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP38
Tbio
Family:  Enzyme
Novelty:  0.06387902
p_int:  0.999935381
p_ni:  0.000064619
Score:  0.997
Data Source:  BioPlex,STRINGDB
POP1
Tbio
Family:  Enzyme
Novelty:  2.92497626
p_int:  0.999798394
p_ni:  0.000201606
Score:  0.985
Data Source:  BioPlex,STRINGDB
POP5
Tbio
Family:  Enzyme
Novelty:  0.02459167
p_int:  0.999500523
p_ni:  0.000049559
p_wrong:  0.000449918
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPP30
Tbio
Family:  Enzyme
Novelty:  0.01375777
p_int:  0.973828484
p_ni:  0.026171516
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.22

PubMed score by year
PubTator Score  11.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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