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Tbio
CIAO2A
Cytosolic iron-sulfur assembly component 2A

Protein Summary
Description
Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:23891004). As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2, connecting cytosolic iron-sulfur protein maturation with cellular iron regulation (PubMed:23891004). May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 (PubMed:25716227).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300030
  • ENSP00000300030
  • ENSG00000166797
  • ENST00000380290
  • ENSP00000369644
  • ENST00000557835
  • ENSP00000454079

Symbol
  • CIA2A
  • FAM96A
  • CIA2A
  • FAM96A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
virus perturbation
0.96
transcription factor binding site profile
0.95
disease perturbation
0.79
transcription factor
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.88   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.88   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (20)
CIAO1
Tbio
Novelty:  0.03999673
p_int:  0.999999142
p_ni:  8.58e-7
Score:  0.959
Data Source:  BioPlex,STRINGDB
CIAO3
Tbio
Novelty:  0.00627147
p_int:  0.999965163
p_ni:  0.000023136
p_wrong:  0.000011701
Score:  0.749
Data Source:  BioPlex,STRINGDB
IREB2
Tbio
Novelty:  0.00300491
p_int:  0.999659718
p_ni:  0.000340211
p_wrong:  7.2e-8
Score:  0.531
Data Source:  BioPlex,STRINGDB
MMS19
Tbio
Novelty:  0.01978769
Score:  0.869
Data Source:  STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
Score:  0.67
Data Source:  STRINGDB
CIAPIN1
Tbio
Novelty:  0.01359005
Score:  0.664
Data Source:  STRINGDB
C9orf64
Tdark
Novelty:  0.66704146
Score:  0.639
Data Source:  STRINGDB
NDOR1
Tbio
Family:  Enzyme
Novelty:  0.07400532
Score:  0.637
Data Source:  STRINGDB
TMEM208
Tdark
Novelty:  0.63059333
Score:  0.605
Data Source:  STRINGDB
NUBP2
Tbio
Novelty:  0.01136095
Score:  0.561
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein B measurement
1
35
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 8.88
PubMed score by year
PubTator Score 4.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title