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Tbio
TFB2M
Dimethyladenosine transferase 2, mitochondrial

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366514
  • ENSP00000355471
  • ENSG00000162851

Symbol
  • NS5ATP5
  • Hkp1
  • mtTFB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
interacting protein
0.85
histone modification site profile
0.73
transcription factor binding site profile
0.73
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.64   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (316)
CD70
Tbio
Novelty:  0.00420393
p_int:  0.944412108
p_ni:  0.055587892
Score:  0.188
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.910029427
p_ni:  0.089970573
Data Source:  BioPlex
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.770127315
p_ni:  0.229872685
Data Source:  BioPlex
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
Score:  0.999
Data Source:  Reactome,STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.998
Data Source:  Reactome,STRINGDB
NRF1
Tbio
Family:  TF
Novelty:  0.00543248
Score:  0.954
Data Source:  STRINGDB
PPRC1
Tbio
Novelty:  0.00182088
Score:  0.947
Data Source:  STRINGDB
PPARGC1A
Tbio
Novelty:  0.0003625
Score:  0.947
Data Source:  STRINGDB
GABPA
Tbio
Family:  TF
Novelty:  0.01731451
Score:  0.942
Data Source:  STRINGDB
HCFC1
Tbio
Novelty:  0.00440762
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Mitochondrial biogenesis
Reactome
Mitochondrial transcription initiation
Reactome
Organelle biogenesis and maintenance
Reactome
Transcription from mitochondrial promoters
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Mitochondrial biogenesis
Mitochondrial transcription initiation
Organelle biogenesis and maintenance
Transcription from mitochondrial promoters
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemolysis
1
1
0
21.2
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemolysis
0
21.2
15.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor B2, mitochondrial
VGNC:10935
457873
Macaque
transcription factor B2, mitochondrial
703287
Mouse
MGI:107937
15278
Rat
RGD:1307091
289307
Dog
transcription factor B2, mitochondrial
VGNC:47289
480102
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor B2, mitochondrial
Macaque
transcription factor B2, mitochondrial
Mouse
Rat
Dog
transcription factor B2, mitochondrial
Publication Statistics
PubMed Score 36.64
PubMed score by year
PubTator Score 27.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title