Tbio PDZD7 PDZ domain-containing protein 7

Protein Summary

Description

In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1. This gene encodes a ciliary protein homologous to proteins which are mutated in Usher syndrome patients, and mutations and translocations involving this gene have been associated with two types of Usher syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

Uniprot Accession IDs

• Q9H5P4
• D5FJ77
• Q8N321

Gene Name

• PDZD7

Ensembl ID

• ENST00000370215
• ENSP00000359234
• ENSG00000186862
• ENST00000433616
• ENSP00000412533
• ENST00000619208
• ENSP00000480489

Symbol

• PDZK7
• PDZK7
• DFNB57

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
transcription factor	0.67
tissue sample	0.61
cell line	0.56
histone modification site profile	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 52   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0