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Tdark
TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

Protein Summary
Description
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. TAF1D is a member of the SL1 complex, which includes TBP (MIM 600075) and TAF1A (MIM 604903), TAF1B (MIM 604904), and TAF1C (MIM 604905), and plays a role in RNA polymerase I transcription (Wang et al., 2004 [PubMed 15520167]; Gorski et al., 2007 [PubMed 17318177]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323981
  • ENSP00000314971
  • ENSG00000166012
  • ENST00000448108
  • ENSP00000410409
  • ENST00000526015
  • ENSP00000435087

Symbol
  • JOSD3
  • JOSD3
  • RAFI41
  • TAFI41
  • TAF(I)41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
transcription factor binding site profile
0.8
cellular component
0.73
disease
0.66
kinase perturbation
0.66


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit D
VGNC:3055
451484
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit D
696602
Mouse
MGI:1922566
75316
Rat
RGD:1309627
363017
Horse
TATA-box binding protein associated factor, RNA polymerase I subunit D
VGNC:23850
100058508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TATA-box binding protein associated factor, RNA polymerase I subunit D
Macaque
TATA-box binding protein associated factor, RNA polymerase I subunit D
Mouse
Rat
Horse
TATA-box binding protein associated factor, RNA polymerase I subunit D
Pathways (12)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (104)
1 – 10 of 104
TAF1B
Tbio
Family: Enzyme
Novelty: 0.10174314
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
TAF1A
Tbio
Family: Enzyme
Novelty: 0.10734794
p_int: 0.999963342
p_ni: 0.000036657
Score: 0.996
Data Source: BioPlex,STRINGDB
TAF1C
Tbio
Family: Enzyme
Novelty: 0.11112315
p_int: 0.999574357
p_ni: 0.000425642
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
TRIM44
Tbio
Novelty: 0.00483553
p_int: 0.998728999
p_ni: 0.001270976
p_wrong: 2.5e-8
Score: 0.518
Data Source: BioPlex,STRINGDB
MECP2
Tchem
Family: TF
Novelty: 0.00051767
p_int: 0.998566333
p_ni: 0.001433004
p_wrong: 6.63e-7
Score: 0.176
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.997320487
p_ni: 0.002671503
p_wrong: 0.00000801
Data Source: BioPlex
RPL18A
Tbio
Novelty: 0.04612948
p_int: 0.996277917
p_ni: 0.003722081
p_wrong: 2e-9
Score: 0.296
Data Source: BioPlex,STRINGDB
RRP8
Tbio
Family: Enzyme
Novelty: 0.04922797
p_int: 0.995942303
p_ni: 0.004057694
p_wrong: 3e-9
Score: 0.537
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.995925896
p_ni: 0.004074101
p_wrong: 3e-9
Score: 0.554
Data Source: BioPlex,STRINGDB
RPL14
Tbio
Novelty: 0.01600377
p_int: 0.989951634
p_ni: 0.009982918
p_wrong: 0.000065447
Score: 0.517
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  3.60

PubMed score by year
PubTator Score  0.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer