You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PIEZO2
Piezo-type mechanosensitive ion channel component 2

Protein Summary
Description
Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302079
  • ENSP00000303316
  • ENSG00000154864
  • ENST00000503781
  • ENSP00000421377
  • ENST00000580640
  • ENSP00000463094

Symbol
  • C18orf30
  • C18orf58
  • FAM38B
  • DA3
  • DA5
  • MWKS
  • DAIPT
  • FAM38B
  • HsT748
  • HsT771
  • FAM38B2
  • C18orf30
  • C18orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
phenotype
0.83
kinase perturbation
0.71
cell type or tissue
0.68
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.9   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.9   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
58.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
58.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
piezo type mechanosensitive ion channel component 2
VGNC:7327
455495
Mouse
MGI:1918781
667742
Rat
RGD:1582973
307380
Dog
piezo type mechanosensitive ion channel component 2
VGNC:44529
490554
Cow
piezo type mechanosensitive ion channel component 2
VGNC:32865
522631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
piezo type mechanosensitive ion channel component 2
Mouse
Rat
Dog
piezo type mechanosensitive ion channel component 2
Cow
piezo type mechanosensitive ion channel component 2
Protein Structure (0 Structures, 8 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (44)
1 – 10 of 44
MYH3
Tbio
Novelty: 0.00544794
Score: 0.805
Data Source: STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.723
Data Source: STRINGDB
TRPV1
Tclin
Family: IC
Novelty: 0.00039493
Score: 0.668
Data Source: STRINGDB
TMIE
Tbio
Novelty: 0.02939225
Score: 0.653
Data Source: STRINGDB
TRPA1
Tclin
Family: IC
Novelty: 0.00093648
Score: 0.65
Data Source: STRINGDB
TMC2
Tbio
Family: IC
Novelty: 0.03655557
Score: 0.648
Data Source: STRINGDB
STOML3
Tbio
Novelty: 0.0587281
Score: 0.647
Data Source: STRINGDB
TMC1
Tbio
Family: IC
Novelty: 0.00609628
Score: 0.641
Data Source: STRINGDB
MYH8
Tbio
Novelty: 0.01020559
Score: 0.64
Data Source: STRINGDB
TRO
Tbio
Novelty: 0.02850833
Score: 0.636
Data Source: STRINGDB
Publication Statistics
PubMed Score  143.90

PubMed score by year
PubTator Score  63.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer