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Tchem
SUV39H2
Histone-lysine N-methyltransferase SUV39H2

Protein Summary
Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chroma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313519
  • ENSP00000319208
  • ENSG00000152455
  • ENST00000354919
  • ENSP00000346997
  • ENST00000378325
  • ENSP00000367576

Symbol
  • KMT1B
  • KMT1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.94
histone modification site profile
0.89
gene perturbation
0.86
transcription factor perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.09   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.09   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 458
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (458)
CHEMBL4587289
Rendered image for CHEMBL4587289
CHEMBL4553838
Rendered image for CHEMBL4553838
CHEMBL4563069
Rendered image for CHEMBL4563069
CHEMBL4520078
Rendered image for CHEMBL4520078
CHEMBL4551654
Rendered image for CHEMBL4551654
CHEMBL4556599
Rendered image for CHEMBL4556599
CHEMBL4556449
Rendered image for CHEMBL4556449
CHEMBL4457187
Rendered image for CHEMBL4457187
CHEMBL4534136
Rendered image for CHEMBL4534136
CHEMBL4551056
Rendered image for CHEMBL4551056
Protein-Protein Interactions (125)
AP4E1
Tdark
Novelty:  0.09773225
p_int:  1
Score:  0.63
Data Source:  BioPlex,STRINGDB
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.999566117
p_ni:  0.000433883
Score:  0.558
Data Source:  BioPlex,STRINGDB
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
p_int:  0.997645134
p_ni:  0.00235486
p_wrong:  6e-9
Score:  0.303
Data Source:  BioPlex,STRINGDB
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.977871634
p_ni:  0.022128302
p_wrong:  6.4e-8
Score:  0.383
Data Source:  BioPlex,STRINGDB
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.919126389
p_ni:  0.080873611
Score:  0.388
Data Source:  BioPlex,STRINGDB
AP4S1
Tdark
Novelty:  0.1142558
p_int:  0.879595442
p_ni:  1.7e-8
p_wrong:  0.120404541
Score:  0.622
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.788539732
p_ni:  0.211460268
Data Source:  BioPlex
CBX1
Tbio
Family:  Epigenetic
Novelty:  0.00343221
p_int:  0.785512238
p_ni:  0.214487756
p_wrong:  6e-9
Score:  0.719
Data Source:  BioPlex,STRINGDB
AP4M1
Tbio
Novelty:  0.00142961
p_int:  0.757506955
p_ni:  2.51e-7
p_wrong:  0.242492794
Score:  0.629
Data Source:  BioPlex,STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.868
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
PKMTs methylate histone lysines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
63
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
63
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of variegation 3-9 homolog 2
VGNC:5796
466014
Macaque
suppressor of variegation 3-9 homolog 2
697378
Mouse
MGI:1890396
64707
Rat
RGD:1306969
364785
Dog
suppressor of variegation 3-9 homolog 2
477995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of variegation 3-9 homolog 2
Macaque
suppressor of variegation 3-9 homolog 2
Mouse
Rat
Dog
suppressor of variegation 3-9 homolog 2
Publication Statistics
PubMed Score 45.09
PubMed score by year
PubTator Score 22.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title