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Tchem
SLC32A1
Vesicular inhibitory amino acid transporter

Protein Summary
Description
Involved in the uptake of GABA and glycine into the synaptic vesicles. The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217420
  • ENSP00000217420
  • ENSG00000101438

Symbol
  • VGAT
  • VIAAT
  • VGAT
  • VIAAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cellular component
0.92
disease perturbation
0.68
transcription factor binding site profile
0.66
PubMedID
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 446.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
vigabatrin
Rendered image for vigabatrin
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
2
1.1
67.1
1
1
1
10
1
1
0
1.1
6.1
body mass index
1
1
1
5.2
insulin sensitivity measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
67.1
1
10
0
1.1
6.1
body mass index
1
5.2
insulin sensitivity measurement
1
5.2
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 32 member 1
VGNC:9984
469940
Macaque
solute carrier family 32 member 1
698315
Mouse
MGI:1194488
22348
Rat
RGD:621402
83612
Dog
solute carrier family 32 member 1
VGNC:46356
485870
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 32 member 1
Macaque
solute carrier family 32 member 1
Mouse
Rat
Dog
solute carrier family 32 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H598-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (14)
GABA synthesis, release, reuptake and degradation (R-HSA-888590)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA synthesis, release, reuptake and degradation
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
SLC-mediated transmembrane transport
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA synthesis, release, reuptake and degradation
Neuronal System
Neurotransmitter release cycle
SLC-mediated transmembrane transport
Transmission across Chemical Synapses
Protein-Protein Interactions (254)
1 – 10 of 254
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.995177602
p_ni:  0.003436163
p_wrong:  0.001386235
Score:  0.252
Data Source:  BioPlex,STRINGDB
CST1
Tbio
Novelty:  0.02399609
p_int:  0.969922929
p_ni:  0.02761684
p_wrong:  0.002460231
Score:  0.187
Data Source:  BioPlex,STRINGDB
GAD1
Tbio
Family:  Enzyme
Novelty:  0.00067443
Score:  0.999
Data Source:  STRINGDB
GAD2
Tbio
Family:  Enzyme
Novelty:  0.00058427
Score:  0.994
Data Source:  STRINGDB
SLC17A7
Tbio
Family:  Transporter
Novelty:  0.00165722
Score:  0.988
Data Source:  STRINGDB
SLC17A6
Tbio
Family:  Transporter
Novelty:  0.00163193
Score:  0.987
Data Source:  STRINGDB
SYT1
Tbio
Novelty:  0.00176103
Score:  0.976
Data Source:  STRINGDB
SLC18A3
Tchem
Family:  Transporter
Novelty:  0.00169007
Score:  0.975
Data Source:  STRINGDB
SNAP25
Tclin
Novelty:  0.00148905
Score:  0.973
Data Source:  STRINGDB
SLC17A8
Tbio
Family:  Transporter
Novelty:  0.00647654
Score:  0.959
Data Source:  STRINGDB
Publication Statistics
PubMed Score  446.79

PubMed score by year
PubTator Score  53.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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