Tbio HEATR1 HEAT repeat-containing protein 1

Protein Summary

Description

Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.

Uniprot Accession IDs

• Q9H583
• Q5T3Q8
• Q6P197
• Q9NW23

Gene Name

• HEATR1

Ensembl ID

• ENST00000366582
• ENSP00000355541
• ENSG00000119285

Symbol

• BAP28
• UTP10
• BAP28
• UTP10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.95
hub protein	0.94
histone modification site profile	0.87
virus perturbation	0.83
transcription factor binding site profile	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Heat Repeat-containing Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Heat Repeat-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 57   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.74   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0