You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HEATR1
HEAT repeat-containing protein 1

Protein Summary
Description
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366582
  • ENSP00000355541
  • ENSG00000119285

Symbol
  • BAP28
  • UTP10
  • BAP28
  • UTP10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
hub protein
0.94
histone modification site profile
0.87
virus perturbation
0.83
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.29   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.29   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (340)
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.999998194
p_ni:  0.000001806
Score:  0.175
Data Source:  BioPlex,STRINGDB
GFAP
Tbio
Novelty:  0.00020932
p_int:  0.987763816
p_ni:  0.012222034
p_wrong:  0.00001415
Score:  0.177
Data Source:  BioPlex,STRINGDB
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.949179487
p_ni:  0.050802843
p_wrong:  0.00001767
Data Source:  BioPlex
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.897980232
p_ni:  0.102019768
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.889872341
p_ni:  0.110127287
p_wrong:  3.72e-7
Data Source:  BioPlex
LAMP3
Tbio
Novelty:  0.01677383
p_int:  0.798006601
p_ni:  0.201993399
Data Source:  BioPlex
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.797013754
p_ni:  0.202986246
Score:  0.177
Data Source:  BioPlex,STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.775492768
p_ni:  0.22450712
p_wrong:  1.12e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
WDR36
Tbio
Novelty:  0.02010676
Score:  0.999
Data Source:  STRINGDB
WDR3
Tbio
Novelty:  0.15410886
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
65.6
platelet crit
1
1
1
61.4
autoimmune thyroid disease
1
1
0
1.1
49.5
total cholesterol measurement
1
1
1
36.5
smoking initiation
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
65.6
platelet crit
1
61.4
autoimmune thyroid disease
0
1.1
49.5
total cholesterol measurement
1
36.5
smoking initiation
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
HEAT repeat containing 1
VGNC:1256
457843
Macaque
HEAT repeat containing 1
717649
Mouse
MGI:2442524
217995
Rat
Dog
HEAT repeat containing 1
VGNC:41633
479192
Species
Name
OMA
EggNOG
Inparanoid
Chimp
HEAT repeat containing 1
Macaque
HEAT repeat containing 1
Mouse
Rat
Dog
HEAT repeat containing 1
Publication Statistics
PubMed Score 11.29
PubMed score by year
PubTator Score 4.73
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Text