ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2
Protein Summary
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
- ENST00000319033
- ENSP00000326609
- ENSG00000119523
- ENST00000476832
- ENSP00000417764
- CDG1I
- CDGIi
- CMS14
- NET38
- CMSTA3
- hALPG2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.95 | ||
histone modification site profile | 0.93 | ||
transcription factor binding site profile | 0.73 | ||
cellular component | 0.71 | ||
virus perturbation | 0.68 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.66 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 225 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.66 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 225 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ALG2, alpha-1,3/1,6-mannosyltransferase | VGNC:8926 | 472993 | |||||
Macaque | ALG2, alpha-1,3/1,6-mannosyltransferase | 714850 | ||||||
Mouse | MGI:1914731 | 56737 | ||||||
Rat | RGD:1309940 | 313231 | ||||||
Dog | ALG2, alpha-1,3/1,6-mannosyltransferase | VGNC:37797 | 474780 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
Macaque | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (13)
Reactome (8)
KEGG (3)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective ALG2 causes ALG2-CDG (CDG-1i) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with N-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective ALG2 causes ALG2-CDG (CDG-1i) | ||||
Disease | ||||
Diseases associated with N-glycosylation of proteins | ||||
Gene Ontology Terms (18)
Functions (6)
Components (8)
Processes (4)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (79)
1 – 10 of 79
LAMTOR1
Novelty: 0.04952213
p_int: 0.999999937
p_ni: 5.9e-8
p_wrong: 3e-9
Data Source: BioPlex
TGOLN2
Novelty: 0.005107
p_int: 0.999908886
p_ni: 0.000078174
p_wrong: 0.000012939
Score: 0.196
Data Source: BioPlex,STRINGDB
HMOX2
Family: Enzyme
Novelty: 0.00180703
p_int: 0.999793775
p_ni: 0.00012655
p_wrong: 0.000079675
Score: 0.233
Data Source: BioPlex,STRINGDB
CD79B
Novelty: 0.00227414
p_int: 0.970688526
p_ni: 0.000384949
p_wrong: 0.028926525
Data Source: BioPlex
ALG1
Family: Enzyme
Novelty: 0.012911
Score: 0.972
Data Source: STRINGDB
ALG11
Family: Enzyme
Novelty: 0.00872486
Score: 0.951
Data Source: STRINGDB
PMM2
Family: Enzyme
Novelty: 0.01177513
Score: 0.85
Data Source: STRINGDB
ATP6V0A2
Family: Enzyme
Novelty: 0.00504614
Score: 0.812
Data Source: STRINGDB
DPAGT1
Family: Enzyme
Novelty: 0.00869839
Score: 0.811
Data Source: STRINGDB
ALG14
Family: Enzyme
Novelty: 0.09271278
Score: 0.783
Data Source: STRINGDB
Publication Statistics
PubMed Score 23.66
PubMed score by year
PubTator Score 84.13
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by:
UniProt Keyword