ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.95 | ||
histone modification site profile | 0.93 | ||
transcription factor binding site profile | 0.73 | ||
cellular component | 0.71 | ||
virus perturbation | 0.68 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective ALG2 causes ALG2-CDG (CDG-1i) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with N-glycosylation of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective ALG2 causes ALG2-CDG (CDG-1i) | ||||
Disease | ||||
Diseases associated with N-glycosylation of proteins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 60.4 | |||||
2 | 2 | 0 | 1.1 | 51.4 | |||||
atrophic macular degeneration | 1 | 1 | 0 | 1.1 | 7.6 | ||||
1 | 1 | 0 | 1.1 | 7.6 | |||||
smoking status measurement | 1 | 1 | 0 | 1 | 3.8 | ||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
0 | 1.1 | 60.4 | |||||
0 | 1.1 | 51.4 | |||||
atrophic macular degeneration | 0 | 1.1 | 7.6 | ||||
0 | 1.1 | 7.6 | |||||
smoking status measurement | 0 | 1 | 3.8 | ||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ALG2, alpha-1,3/1,6-mannosyltransferase | VGNC:8926 | 472993 | |||||
Macaque | ALG2, alpha-1,3/1,6-mannosyltransferase | 714850 | ||||||
Mouse | MGI:1914731 | 56737 | ||||||
Rat | RGD:1309940 | 313231 | ||||||
Dog | ALG2, alpha-1,3/1,6-mannosyltransferase | VGNC:37797 | 474780 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
Macaque | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ALG2, alpha-1,3/1,6-mannosyltransferase | |||||
PMID | Year | Title |
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