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Tbio
ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

Protein Summary
Description
Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319033
  • ENSP00000326609
  • ENSG00000119523
  • ENST00000476832
  • ENSP00000417764

Symbol
  • CDG1I
  • CDGIi
  • CMS14
  • NET38
  • CMSTA3
  • hALPG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
histone modification site profile
0.93
transcription factor binding site profile
0.73
cellular component
0.71
virus perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.66   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ALG2, alpha-1,3/1,6-mannosyltransferase
VGNC:8926
472993
Macaque
ALG2, alpha-1,3/1,6-mannosyltransferase
714850
Mouse
MGI:1914731
56737
Rat
RGD:1309940
313231
Dog
ALG2, alpha-1,3/1,6-mannosyltransferase
VGNC:37797
474780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ALG2, alpha-1,3/1,6-mannosyltransferase
Macaque
ALG2, alpha-1,3/1,6-mannosyltransferase
Mouse
Rat
Dog
ALG2, alpha-1,3/1,6-mannosyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H553-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective ALG2 causes ALG2-CDG (CDG-1i)
Reactome
Disease
Reactome
Diseases associated with N-glycosylation of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG2 causes ALG2-CDG (CDG-1i)
Disease
Diseases associated with N-glycosylation of proteins
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (79)
1 – 10 of 79
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.999999937
p_ni: 5.9e-8
p_wrong: 3e-9
Data Source: BioPlex
TGOLN2
Tbio
Novelty: 0.005107
p_int: 0.999908886
p_ni: 0.000078174
p_wrong: 0.000012939
Score: 0.196
Data Source: BioPlex,STRINGDB
HMOX2
Tchem
Family: Enzyme
Novelty: 0.00180703
p_int: 0.999793775
p_ni: 0.00012655
p_wrong: 0.000079675
Score: 0.233
Data Source: BioPlex,STRINGDB
CD79B
Tclin
Novelty: 0.00227414
p_int: 0.970688526
p_ni: 0.000384949
p_wrong: 0.028926525
Data Source: BioPlex
ALG1
Tbio
Family: Enzyme
Novelty: 0.012911
Score: 0.972
Data Source: STRINGDB
ALG11
Tbio
Family: Enzyme
Novelty: 0.00872486
Score: 0.951
Data Source: STRINGDB
PMM2
Tchem
Family: Enzyme
Novelty: 0.01177513
Score: 0.85
Data Source: STRINGDB
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
Score: 0.812
Data Source: STRINGDB
DPAGT1
Tbio
Family: Enzyme
Novelty: 0.00869839
Score: 0.811
Data Source: STRINGDB
ALG14
Tbio
Family: Enzyme
Novelty: 0.09271278
Score: 0.783
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.66

PubMed score by year
PubTator Score  84.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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