Tbio KLHL31 Kelch-like protein 31

Protein Summary

Description

Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Uniprot Accession IDs

• Q9H511
• A6N9J2
• B2RP49

Gene Name

• KLHL31

Ensembl ID

• ENST00000370905
• ENSP00000359942
• ENSG00000124743
• ENST00000407079
• ENSP00000384644

Symbol

• BKLHD6
• KBTBD1
• KLHL
• KLHL
• BKLHD6
• KBTBD1
• bA345L23.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
microRNA	0.61
tissue sample	0.6
cell line	0.53
tissue	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.77   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.77   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0