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Tbio
KLHL31
Kelch-like protein 31

Protein Summary
Description
Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370905
  • ENSP00000359942
  • ENSG00000124743
  • ENST00000407079
  • ENSP00000384644

Symbol
  • BKLHD6
  • KBTBD1
  • KLHL
  • KLHL
  • BKLHD6
  • KBTBD1
  • bA345L23.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
microRNA
0.61
tissue sample
0.6
cell line
0.53
tissue
0.48


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 31
VGNC:3264
472040
Macaque
kelch like family member 31
710672
Mouse
MGI:3045305
244923
Rat
RGD:1560540
315833
Dog
kelch like family member 31
VGNC:42465
481846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like family member 31
Macaque
kelch like family member 31
Mouse
Rat
Dog
kelch like family member 31
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H511-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (83)
1 – 10 of 83
NTMT1
Tbio
Family: Enzyme
Novelty: 0.06322967
Score: 0.81
Data Source: STRINGDB
FSD2
Tbio
Novelty: 0.1302271
Score: 0.782
Data Source: STRINGDB
RPL23A
Tbio
Novelty: 0.02951947
Score: 0.757
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.731
Data Source: STRINGDB
KLHDC1
Tbio
Novelty: 1.2348626
Score: 0.678
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.677
Data Source: STRINGDB
SMPX
Tbio
Novelty: 0.05084864
Score: 0.658
Data Source: STRINGDB
FAM83B
Tbio
Novelty: 0.14293165
Score: 0.655
Data Source: STRINGDB
KLHL30
Tdark
Novelty: 0.91919668
Score: 0.654
Data Source: STRINGDB
UNC45B
Tbio
Novelty: 0.01872121
Score: 0.647
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.29

PubMed score by year
PubTator Score  2.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer