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Tbio
ZNF335
Zinc finger protein 335

Protein Summary
Description
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322927
  • ENSP00000325326
  • ENSG00000198026

Symbol
  • NIF1
  • NIF2
  • NIF-1
  • MCPH10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
biological process
0.91
transcription factor
0.8
molecular function
0.7
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.74   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
3
3
89.4
cognitive function measurement
1
1
1
71.1
triglyceride measurement
1
1
1
58.1
2
1
2
28.6
intelligence
2
1
1
5.7
23.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
89.4
cognitive function measurement
1
71.1
triglyceride measurement
1
58.1
2
28.6
intelligence
1
5.7
23.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 335
VGNC:6302
458293
Macaque
zinc finger protein 335
708282
Mouse
MGI:2682313
329559
Rat
RGD:628751
259270
Dog
zinc finger protein 335
VGNC:48703
485904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 335
Macaque
zinc finger protein 335
Mouse
Rat
Dog
zinc finger protein 335
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4Z2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (36)
1 – 10 of 36
RPSA
Tbio
Novelty: 0.00250446
p_int: 0.995779224
p_ni: 0.001865867
p_wrong: 0.002354909
Score: 0.309
Data Source: BioPlex,STRINGDB
CNOT6
Tbio
Novelty: 0.03605299
Score: 0.904
Data Source: Reactome,STRINGDB
YIPF6
Tdark
Novelty: 0.04316252
Score: 0.759
Data Source: STRINGDB
NCOA6
Tbio
Novelty: 0.00750424
Score: 0.704
Data Source: STRINGDB
WDR62
Tbio
Novelty: 0.02611137
Score: 0.649
Data Source: STRINGDB
CEP135
Tbio
Novelty: 0.03507768
Score: 0.632
Data Source: STRINGDB
PHC1
Tbio
Novelty: 0.01530622
Score: 0.58
Data Source: STRINGDB
STIL
Tbio
Novelty: 0.01053211
Score: 0.577
Data Source: STRINGDB
CDK5RAP2
Tbio
Novelty: 0.00956263
Score: 0.577
Data Source: STRINGDB
CENPJ
Tbio
Novelty: 0.01337231
Score: 0.574
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.74

PubMed score by year
PubTator Score  22.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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