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Tbio
GSTO2
Glutathione S-transferase omega-2

Protein Summary
Description
Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338595
  • ENSP00000345023
  • ENSG00000065621
  • ENST00000369707
  • ENSP00000358721
  • ENST00000450629
  • ENSP00000390986

Symbol
  • GSTO 2-2
  • bA127L20.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cell type or tissue
0.74
gene perturbation
0.74
molecular function
0.63
transcription factor
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.62   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.62   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
65.7
smoking status measurement
2
1
2
33.1
mathematical ability
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
65.7
smoking status measurement
2
33.1
mathematical ability
1
15.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase omega 2
VGNC:12341
450720
Mouse
MGI:1915464
68214
Rat
RGD:1310764
309465
Horse
glutathione S-transferase omega 2
VGNC:18629
100069628
Cow
glutathione S-transferase omega 2
VGNC:29687
613905
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase omega 2
Mouse
Rat
Horse
glutathione S-transferase omega 2
Cow
glutathione S-transferase omega 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H4Y5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (21)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (90)
1 – 10 of 90
EDRF1
Tbio
Novelty:  0.24333657
p_int:  0.999568898
p_ni:  0.000431093
p_wrong:  9e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
RBM12
Tbio
Novelty:  0.10430477
p_int:  0.987817664
p_ni:  0.012182336
Score:  0.21
Data Source:  BioPlex,STRINGDB
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.961985832
p_ni:  0.038014168
Score:  0.188
Data Source:  BioPlex,STRINGDB
GPX4
Tbio
Family:  Enzyme
Novelty:  0.00188213
p_int:  0.795811236
p_ni:  0.204188764
Score:  0.933
Data Source:  BioPlex,STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.9
Data Source:  STRINGDB
GSTM1
Tbio
Family:  Enzyme
Novelty:  0.00023264
Score:  0.898
Data Source:  STRINGDB
HPGDS
Tchem
Family:  Enzyme
Novelty:  0.00019629
Score:  0.898
Data Source:  STRINGDB
GSTP1
Tchem
Family:  Enzyme
Novelty:  0.00045452
Score:  0.889
Data Source:  STRINGDB
GSTA1
Tchem
Family:  Enzyme
Novelty:  0.00308319
Score:  0.874
Data Source:  STRINGDB
FKBP1A
Tclin
Family:  Enzyme
Novelty:  0.00116174
Score:  0.867
Data Source:  STRINGDB
Publication Statistics
PubMed Score  58.62

PubMed score by year
PubTator Score  48.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer