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Tbio
PRDM12
PR domain zinc finger protein 12

Protein Summary
Description
Involved in the positive regulation of histone H3-K9 dimethylation. This gene encodes a transcriptional regulator of sensory neuronal specification that plays a critical role in pain perception. The encoded protein contains an N-terminal PRDI-BF1 and RIZ homology (PR) domain, a SET domain, and three C-terminal C2H2 zinc finger DNA-binding domains. Naturally occurring mutations in this gene are associated with congenital insensitivity to pain (CIP), and hereditary sensory and autonomic neuropathies (HSAN's) affecting peripheral sensory and autonomic neurons. Deregulation of this gene is associated with solid cancers and hematological malignancies including chronic myeloid leukaemia. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253008
  • ENSP00000253008
  • ENSG00000130711

Symbol
  • PFM9
  • PFM9
  • HSAN8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.57
transcription factor
0.56
cell line
0.5
biological process
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (35)
1 – 10 of 35
PRDM11
Tbio
Family:  Epigenetic
Novelty:  0.30063286
Score:  0.75
Data Source:  STRINGDB
EVX1
Tbio
Family:  TF
Novelty:  0.02648873
Score:  0.652
Data Source:  STRINGDB
OR11L1
Tdark
Family:  oGPCR
Novelty:  2.63771662
Score:  0.577
Data Source:  STRINGDB
FNDC3A
Tbio
Novelty:  0.04721453
Score:  0.571
Data Source:  STRINGDB
OR6F1
Tdark
Family:  oGPCR
Novelty:  2.7478574
Score:  0.566
Data Source:  STRINGDB
HMCN2
Tdark
Novelty:  0.27717122
Score:  0.564
Data Source:  STRINGDB
DBX1
Tbio
Family:  TF
Novelty:  0.02105514
Score:  0.555
Data Source:  STRINGDB
EN1
Tbio
Family:  TF
Novelty:  0.00490799
Score:  0.541
Data Source:  STRINGDB
DBX2
Tbio
Family:  TF
Novelty:  0.11816475
Score:  0.513
Data Source:  STRINGDB
NUP35
Tbio
Novelty:  0.0355102
Score:  0.511
Data Source:  STRINGDB
Gene Ontology Terms (14)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
93.3
femoral neck bone mineral density
2
2
2
86.4
body height
3
2
3
82.6
body weights and measures
1
1
1
79.5
red blood cell distribution width
2
2
2
78.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
93.3
femoral neck bone mineral density
2
86.4
body height
3
82.6
body weights and measures
1
79.5
red blood cell distribution width
2
78.7
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685844
381359
Rat
RGD:1586401
688699
Cow
PR/SET domain 12
VGNC:33290
618320
Pig
PR/SET domain 12
100522920
Chicken
PR/SET domain 12
CGNC:2853
417183
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
PR/SET domain 12
Pig
PR/SET domain 12
Chicken
PR/SET domain 12
Publication Statistics
PubMed Score 23.61
PubMed score by year
PubTator Score 12.77
PubTator score by year