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Tbio
PLEKHA4
Pleckstrin homology domain-containing family A member 4

Protein Summary
Description
Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. This gene encodes a pleckstrin homology (PH) domain-containing protein. The PH domain is found near the N-terminus and contains a putative phosphatidylinositol 3, 4, 5-triphosphate-binding motif (PPBM). Elevated expression of this gene has been observed in some melanomas. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263265
  • ENSP00000263265
  • ENSG00000105559
  • ENST00000355496
  • ENSP00000347683

Symbol
  • PEPP1
  • PEPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.88
kinase perturbation
0.66
tissue sample
0.66
transcription factor
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.22   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.22   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
6
96.1
red blood cell distribution width
4
3
5
95.1
serum gamma-glutamyl transferase measurement
1
5
5
94.9
reticulocyte count
6
4
12
94.4
total cholesterol measurement
1
3
3
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
6
96.1
red blood cell distribution width
5
95.1
serum gamma-glutamyl transferase measurement
5
94.9
reticulocyte count
12
94.4
total cholesterol measurement
3
90.9
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing A4
718891
Mouse
MGI:1916467
69217
Rat
RGD:735133
308584
Dog
pleckstrin homology domain containing A4
VGNC:53751
484393
Horse
pleckstrin homology domain containing A4
VGNC:21559
100054587
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pleckstrin homology domain containing A4
Mouse
Rat
Dog
pleckstrin homology domain containing A4
Horse
pleckstrin homology domain containing A4
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H4M7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (27)
1 – 10 of 27
KCNJ6
Tchem
Family:  IC
Novelty:  0.00330353
Score:  0.658
Data Source:  STRINGDB
SYT3
Tbio
Novelty:  0.02593006
Score:  0.65
Data Source:  STRINGDB
PLEK
Tbio
Novelty:  0.00074263
Score:  0.644
Data Source:  STRINGDB
OR6N2
Tdark
Family:  oGPCR
Novelty:  0.67142074
Score:  0.642
Data Source:  STRINGDB
BPIFC
Tdark
Novelty:  0.2764846
Score:  0.601
Data Source:  STRINGDB
KCNC1
Tclin
Family:  IC
Novelty:  0.00252943
Score:  0.595
Data Source:  STRINGDB
PIK3C2A
Tchem
Family:  Kinase
Novelty:  0.0002219
Score:  0.587
Data Source:  STRINGDB
GOLT1A
Tdark
Novelty:  0.28174511
Score:  0.586
Data Source:  STRINGDB
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
Score:  0.582
Data Source:  STRINGDB
MTMR3
Tbio
Family:  Enzyme
Novelty:  0.04961778
Score:  0.541
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.22

PubMed score by year
PubTator Score  0.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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