You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FBXO44
F-box only protein 44

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It is also a member of the NFB42 (neural F Box 42 kDa) family, similar to F-box only protein 2 and F-box only protein 6. Several alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251546
  • ENSP00000251546
  • ENSG00000132879
  • ENST00000251547
  • ENSP00000251547
  • ENST00000376760
  • ENSP00000365951
  • ENST00000376762
  • ENSP00000365953
  • ENST00000376770
  • ENSP00000365961

Symbol
  • FBG3
  • FBX30
  • FBX44
  • FBX6A
  • FBXO6A
  • FBG3
  • FBX30
  • FBX6A
  • Fbx44
  • Fbxo6a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
transcription factor
0.67
tissue sample
0.57
histone modification site profile
0.54
cell line
0.44


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.95   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.95   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box protein 44
714585
Mouse
MGI:1354744
230903
Cow
F-box protein 44
785057
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box protein 44
Mouse
Cow
F-box protein 44
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (335)
1 – 10 of 335
SPA17
Tbio
Novelty: 0.02632554
p_int: 0.999834918
p_ni: 0.000165077
p_wrong: 5e-9
Score: 0.309
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
p_int: 0.994169232
p_ni: 0.005830768
Score: 0.967
Data Source: BioPlex,STRINGDB
CDK13
Tchem
Family: Kinase
Novelty: 0.03084808
p_int: 0.980698192
p_ni: 4.23e-7
p_wrong: 0.019301385
Score: 0.19
Data Source: BioPlex,STRINGDB
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.963349307
p_ni: 0.036650693
p_wrong: 1e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
RBX1
Tbio
Family: Enzyme
Novelty: 0.00596986
Score: 0.959
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.952
Data Source: STRINGDB
FBXW5
Tbio
Novelty: 0.13100873
Score: 0.941
Data Source: STRINGDB
CCNF
Tbio
Novelty: 0.01288697
Score: 0.938
Data Source: STRINGDB
RNF126
Tbio
Family: Enzyme
Novelty: 0.08123801
Score: 0.938
Data Source: STRINGDB
FBH1
Tbio
Family: Enzyme
Novelty: 0.04243458
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.95

PubMed score by year
PubTator Score  2.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer