Tbio SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

Protein Summary

Description

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. This gene encodes a member of the SNF subfamily of helicase proteins. The encoded protein plays a critical role in the restoration of heterochromatin organization and propagation of epigenetic patterns following DNA replication by mediating histone H3/H4 deacetylation. Mutations in this gene are associated with adermatoglyphia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9H4L7
• B7Z799
• Q05D56
• Q96SX1
• Q9H017
• Q9H860
• Q9NPU9
• Q9ULU7

Gene Name

• SMARCAD1

Ensembl ID

• ENST00000354268
• ENSP00000346217
• ENSG00000163104
• ENST00000359052
• ENSP00000351947
• ENST00000457823
• ENSP00000415576
• ENST00000509418
• ENSP00000423286

Symbol

• KIAA1122
• HRZ
• ETL1
• HEL1
• ADERM
• BASNS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
transcription factor binding site profile	0.88
ligand (protein) perturbation	0.83
kinase perturbation	0.81
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Helicase / Dna Helicase / Swi/snf-related Matrix-associated Actin-dependent Regulator Of Chromatin Subfamily A Containing Dead/h Box 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Helicase / Swi/snf-related Matrix-associated Actin-dependent Regulator Of Chromatin Subfamily A Containing Dead/h Box 1

DTO Classes

Protein / Enzyme / Helicase / Dna Helicase / Swi/snf-related Matrix-associated Actin-dependent Regulator Of Chromatin Subfamily A Containing Dead/h Box 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.48   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 125   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.48   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0