Tbio OSBPL3 Oxysterol-binding protein-related protein 3

Protein Summary

Description

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9H4L5
• A4D167
• A4D168
• A4D169
• A4D170
• A4D171
• A4D172
• B8ZZ79
• B8ZZP0
• O14591
• O43357
• O43358
• Q8N702
• Q8N703
• Q8N704
• Q8NFH0
• Q8NFH1
• Q8NI12
• Q8NI13
• Q9BZF4
• Q9UED6
• ORP-3

Gene Name

• OSBPL3

Ensembl ID

• ENST00000313367
• ENSP00000315410
• ENSG00000070882
• ENST00000396429
• ENSP00000379706
• ENST00000396431
• ENSP00000379708
• ENST00000409069
• ENSP00000386953
• ENST00000409452
• ENSP00000386801
• ENST00000409555
• ENSP00000386990
• ENST00000409759
• ENSP00000386325
• ENST00000409863
• ENSP00000386429

Symbol

• KIAA0704
• ORP3
• OSBP3
• ORP3
• ORP-3
• OSBP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.96
transcription factor binding site profile	0.93
interacting protein	0.81
histone modification site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.1   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.1   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0