Tbio OSBPL3 Oxysterol-binding protein-related protein 3

Protein Summary

Description

Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9H4L5
• A4D167
• A4D168
• A4D169
• A4D170
• A4D171
• A4D172
• B8ZZ79
• B8ZZP0
• O14591
• O43357
• O43358
• Q8N702
• Q8N703
• Q8N704
• Q8NFH0
• Q8NFH1
• Q8NI12
• Q8NI13
• Q9BZF4
• Q9UED6
• ORP-3

Gene Name

• OSBPL3

Ensembl ID

• ENST00000313367
• ENSP00000315410
• ENSG00000070882
• ENST00000396429
• ENSP00000379706
• ENST00000396431
• ENSP00000379708
• ENST00000409069
• ENSP00000386953
• ENST00000409452
• ENSP00000386801
• ENST00000409555
• ENSP00000386990
• ENST00000409759
• ENSP00000386325
• ENST00000409863
• ENSP00000386429

Symbol

• KIAA0704
• ORP3
• OSBP3
• ORP3
• ORP-3
• OSBP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.96
transcription factor binding site profile	0.93
interacting protein	0.81
histone modification site profile	0.79

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	2	3		83.6
self reported educational attainment	EFO_0004784	1	1	1		45.6

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3		83.6
self reported educational attainment	EFO_0004784	1		45.6

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Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	oxysterol binding protein like 3	VGNC:4455	463296
Macaque	oxysterol binding protein like 3		703212
Mouse	oxysterol binding protein-like 3	MGI:1918970	71720
Rat	oxysterol binding protein-like 3	RGD:1564287	362360
Dog	oxysterol binding protein like 3	VGNC:44155	482363

Species	Name	OMA	EggNOG	Inparanoid
Chimp	oxysterol binding protein like 3
Macaque	oxysterol binding protein like 3
Mouse	oxysterol binding protein-like 3
Rat	oxysterol binding protein-like 3
Dog	oxysterol binding protein like 3

Pathways (5)

Reactome (5)

Bile acid and bile salt metabolism (R-HSA-194068)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Metabolism of lipids	740 targets	R-HSA-556833
Reactome	Metabolism of steroids	151 targets	R-HSA-8957322
Reactome	Synthesis of bile acids and bile salts	34 targets	R-HSA-192105

Name	Explore in Pharos	Explore in Source
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Metabolism	2112 targets	R-HSA-1430728
Metabolism of lipids	740 targets	R-HSA-556833
Metabolism of steroids	151 targets	R-HSA-8957322
Synthesis of bile acids and bile salts	34 targets	R-HSA-192105

Gene Ontology Terms (13)

Functions (4)

Components (8)

Processes (1)

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1 – 4 of 4

GO Term	Evidence	Assigned by
cholesterol binding	Inferred from Direct Assay (IDA)	BHF-UCL
lipid binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sterol binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sterol transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

VAPB

Tbio

Novelty: 0.00542377

p_int: 0.999999917

p_ni: 8.3e-8

Score: 0.793

Data Source: BioPlex,STRINGDB

NOP53

Tbio

Novelty: 0.00353077

p_int: 0.999998053

p_ni: 0.000001946

Data Source: BioPlex

VAPA

Tbio

Novelty: 0.00169209

p_int: 0.999983021

p_ni: 0.000016979

Score: 0.787

Data Source: BioPlex,STRINGDB

ZFPL1

Tbio

Novelty: 0.1829181

p_int: 0.999969045

p_ni: 0.000030955

Score: 0.165

Data Source: BioPlex,STRINGDB

KLRD1

Tbio

Novelty: 0.00218019

p_int: 0.999967074

p_ni: 0.000032926

Data Source: BioPlex

AURKA

Tchem

Family: Kinase

Novelty: 0.0010868

p_int: 0.999940439

p_ni: 0.000059561

Data Source: BioPlex

ERH

Tbio

Novelty: 0.00711649

p_int: 0.99994035

p_ni: 0.00005965

Data Source: BioPlex

PHTF2

Tdark

Novelty: 0.52825058

p_int: 0.999638921

p_ni: 0.000361079

Data Source: BioPlex

CPNE2

Tdark

Novelty: 0.24188419

p_int: 0.999598654

p_ni: 0.000401345

p_wrong: 2e-9

Data Source: BioPlex

TSPYL1

Tbio

Novelty: 0.06381144

p_int: 0.999473831

p_ni: 0.000526167

p_wrong: 2e-9

Data Source: BioPlex

Publication Statistics

PubMed Score  17.82

PubMed score by year

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PubTator Score  8.58

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Alternative splicing
Cell membrane
Cell projection
Complete proteome
Cytoplasm
Endoplasmic reticulum
Lipid transport
Lipid-binding
Membrane
Nucleus

GWAS Trait Find Similar Targets

mathematical ability
self reported educational attainment

MGI Phenotype Find Similar Targets

hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
skeleton phenotype