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Tbio
OSBPL3
Oxysterol-binding protein-related protein 3

Protein Summary
Description
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding doma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313367
  • ENSP00000315410
  • ENSG00000070882
  • ENST00000396429
  • ENSP00000379706
  • ENST00000396431
  • ENSP00000379708
  • ENST00000409069
  • ENSP00000386953
  • ENST00000409452
  • ENSP00000386801
  • ENST00000409555
  • ENSP00000386990
  • ENST00000409759
  • ENSP00000386325
  • ENST00000409863
  • ENSP00000386429

Symbol
  • KIAA0704
  • ORP3
  • OSBP3
  • ORP3
  • ORP-3
  • OSBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.96
transcription factor binding site profile
0.93
interacting protein
0.81
histone modification site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.46   (req: < 5)
View Publications
Gene RIFs: 8   (req: <= 3)
View Gene RIFs
Antibodies: 102   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.46   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
43 targets
R-HSA-194068
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Metabolism of lipids
740 targets
R-HSA-556833
Reactome
Metabolism of steroids
151 targets
R-HSA-8957322
Reactome
Synthesis of bile acids and bile salts
34 targets
R-HSA-192105
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
43 targets
R-HSA-194068
Metabolism
2112 targets
R-HSA-1430728
Metabolism of lipids
740 targets
R-HSA-556833
Metabolism of steroids
151 targets
R-HSA-8957322
Synthesis of bile acids and bile salts
34 targets
R-HSA-192105
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
cholesterol binding
Inferred from Direct Assay (IDA)
BHF-UCL
lipid binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
sterol binding
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
sterol transporter activity
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (46)
1 – 10 of 46
VAPB
Tbio
Novelty: 0.00566042
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.793
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00473377
p_int: 0.999998053
p_ni: 0.000001946
Data Source: BioPlex
VAPA
Tbio
Novelty: 0.0022428
p_int: 0.999983021
p_ni: 0.000016979
Score: 0.787
Data Source: BioPlex,STRINGDB
ZFPL1
Tbio
Novelty: 0.06292606
p_int: 0.999969045
p_ni: 0.000030955
Score: 0.165
Data Source: BioPlex,STRINGDB
KLRD1
Tbio
Novelty: 0.00257574
p_int: 0.999967074
p_ni: 0.000032926
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.00069833
p_int: 0.999940439
p_ni: 0.000059561
Data Source: BioPlex
ERH
Tbio
Novelty: 0.00493543
p_int: 0.99994035
p_ni: 0.00005965
Data Source: BioPlex
PHTF2
Tdark
Novelty: 2
p_int: 0.999638921
p_ni: 0.000361079
Data Source: BioPlex
CPNE2
Tdark
Novelty: 0.33799663
p_int: 0.999598654
p_ni: 0.000401345
p_wrong: 2e-9
Data Source: BioPlex
TSPYL1
Tbio
Novelty: 0.09347181
p_int: 0.999473831
p_ni: 0.000526167
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  8.46

PubMed score by year
PubTator Score  8.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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