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Tbio
OSBPL3
Oxysterol-binding protein-related protein 3

Protein Summary
Description
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324). Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204). The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204). With VAPA, may regulate ER morphology (PubMed:16143324). Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267). Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324). Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding doma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313367
  • ENSP00000315410
  • ENSG00000070882
  • ENST00000396429
  • ENSP00000379706
  • ENST00000396431
  • ENSP00000379708
  • ENST00000409069
  • ENSP00000386953
  • ENST00000409452
  • ENSP00000386801
  • ENST00000409555
  • ENSP00000386990
  • ENST00000409759
  • ENSP00000386325
  • ENST00000409863
  • ENSP00000386429

Symbol
  • KIAA0704
  • ORP3
  • OSBP3
  • ORP3
  • ORP-3
  • OSBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.96
transcription factor binding site profile
0.93
interacting protein
0.81
histone modification site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.82   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
83.6
self reported educational attainment
1
1
1
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
83.6
self reported educational attainment
1
45.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 3
VGNC:4455
463296
Macaque
oxysterol binding protein like 3
703212
Mouse
MGI:1918970
71720
Rat
RGD:1564287
362360
Dog
oxysterol binding protein like 3
VGNC:44155
482363
Species
Name
OMA
EggNOG
Inparanoid
Chimp
oxysterol binding protein like 3
Macaque
oxysterol binding protein like 3
Mouse
Rat
Dog
oxysterol binding protein like 3
Pathways (5)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (46)
1 – 10 of 46
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.793
Data Source: BioPlex,STRINGDB
NOP53
Tbio
Novelty: 0.00353077
p_int: 0.999998053
p_ni: 0.000001946
Data Source: BioPlex
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999983021
p_ni: 0.000016979
Score: 0.787
Data Source: BioPlex,STRINGDB
ZFPL1
Tbio
Novelty: 0.1829181
p_int: 0.999969045
p_ni: 0.000030955
Score: 0.165
Data Source: BioPlex,STRINGDB
KLRD1
Tbio
Novelty: 0.00218019
p_int: 0.999967074
p_ni: 0.000032926
Data Source: BioPlex
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999940439
p_ni: 0.000059561
Data Source: BioPlex
ERH
Tbio
Novelty: 0.00711649
p_int: 0.99994035
p_ni: 0.00005965
Data Source: BioPlex
PHTF2
Tdark
Novelty: 0.52825058
p_int: 0.999638921
p_ni: 0.000361079
Data Source: BioPlex
CPNE2
Tdark
Novelty: 0.24188419
p_int: 0.999598654
p_ni: 0.000401345
p_wrong: 2e-9
Data Source: BioPlex
TSPYL1
Tbio
Novelty: 0.06381144
p_int: 0.999473831
p_ni: 0.000526167
p_wrong: 2e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  17.82

PubMed score by year
PubTator Score  8.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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