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Tbio
SENP3
Sentrin-specific protease 3

Protein Classes
Protein Summary
Description
Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific protease ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321337
  • ENSP00000314029
  • ENSG00000161956
  • ENST00000429205
  • ENSP00000403712

Symbol
  • SSP3
  • SUSP3
  • SSP3
  • Ulp1
  • SMT3IP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.8
cellular component
0.79
cell type or tissue
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.35   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.35   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 3
VGNC:14195
100551502
Mouse
MGI:2158736
80886
Rat
RGD:1312040
303245
Dog
SUMO1/sentrin/SMT3 specific peptidase 3
607655
Horse
SUMO1/sentrin/SMT3 specific peptidase 3
102148314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SUMO specific peptidase 3
Mouse
Rat
Dog
SUMO1/sentrin/SMT3 specific peptidase 3
Horse
SUMO1/sentrin/SMT3 specific peptidase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4L4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (231)
1 – 10 of 231
NOL9
Tdark
Family: Enzyme
Novelty: 0.05830272
p_int: 0.999614669
p_ni: 0.000385331
Score: 0.979
Data Source: BioPlex,STRINGDB
WDR18
Tbio
Novelty: 0.03015818
p_int: 0.999500332
p_ni: 0.000499668
Score: 0.998
Data Source: BioPlex,STRINGDB
PHF19
Tbio
Family: Epigenetic
Novelty: 0.02289037
p_int: 0.900722242
p_ni: 0.099277758
Score: 0.242
Data Source: BioPlex,STRINGDB
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.876797832
p_ni: 0.123202168
Data Source: BioPlex
H2AFB1
Tbio
Novelty: 0.08770329
p_int: 0.871748939
p_ni: 0.128250759
p_wrong: 3.02e-7
Data Source: BioPlex
TNFRSF13B
Tbio
Novelty: 0.00338954
p_int: 0.799975362
p_ni: 0.200024638
Score: 0.189
Data Source: BioPlex,STRINGDB
TEX10
Tdark
Novelty: 0.12988812
Score: 0.998
Data Source: STRINGDB
PELP1
Tbio
Novelty: 0.00817675
Score: 0.994
Data Source: STRINGDB
LAS1L
Tbio
Novelty: 0.15470637
Score: 0.981
Data Source: STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  242.35

PubMed score by year
PubTator Score  39.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer