Tbio SMDT1 Essential MCU regulator, mitochondrial

Protein Summary

Description

Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988). This gene encodes a core regulatory component of a calcium channel in the mitochondrial inner membrane. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q9H4I9
• B2R5D1
• Q8TAB9

Gene Name

• SMDT1

Ensembl ID

• ENST00000331479
• ENSP00000327467
• ENSG00000183172
• ENST00000571525
• ENSP00000459368
• ENSG00000272901
• ENST00000607293
• ENSP00000475471
• ENSG00000272835
• ENST00000615504
• ENSP00000485029
• ENSG00000274112

Symbol

• C22orf32
• EMRE
• DDDD
• EMRE
• C22orf32

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
small molecule perturbation	0.77
kinase perturbation	0.66
transcription factor binding site profile	0.64
tissue sample	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.11   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 19   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.11   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0