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Tdark
SERHL2
Serine hydrolase-like protein 2

Protein Summary
Description
Probable serine hydrolase. May be related to cell muscle hypertrophy.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327678
  • ENSP00000331376
  • ENSG00000183569
  • ENST00000335879
  • ENSP00000336578
  • ENST00000407614
  • ENSP00000385691

Symbol
  • SERHL
  • dJ222E13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.76
histone modification site profile
0.7
cell type or tissue
0.57
tissue sample
0.56
small molecule perturbation
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
1
1
0
23.6
41.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
influenza A (H1N1)
0
23.6
41.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1890404
68607
Rat
RGD:1563386
500911
Dog
serine hydrolase like 2
474481
Horse
serine hydrolase like 2
100071013
Cow
serine hydrolase like 2 [Source:HGNC Symbol;Acc:HGNC:29446]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
serine hydrolase like 2
Horse
serine hydrolase like 2
Cow
serine hydrolase like 2 [Source:HGNC Symbol;Acc:HGNC:29446]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4I8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (25)
1 – 10 of 25
MICAL1
Tbio
Family: Enzyme
Novelty: 0.02668048
p_int: 0.995500667
p_ni: 0.004496484
p_wrong: 0.000002849
Score: 0.203
Data Source: BioPlex,STRINGDB
DAAM1
Tbio
Novelty: 0.02143008
p_int: 0.955945605
p_ni: 0.044054395
Score: 0.189
Data Source: BioPlex,STRINGDB
CSNK1G3
Tbio
Family: Kinase
Novelty: 0.07584067
p_int: 0.905346631
p_ni: 0.094651529
p_wrong: 0.00000184
Score: 0.183
Data Source: BioPlex,STRINGDB
PAG1
Tbio
Novelty: 0.01390911
p_int: 0.903630169
p_ni: 0.096368288
p_wrong: 0.000001544
Score: 0.177
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.08250797
p_int: 0.897023776
p_ni: 0.102976219
p_wrong: 5e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
UBE3A
Tbio
Family: Enzyme
Novelty: 0.00149368
p_int: 0.888974834
p_ni: 0.111023899
p_wrong: 0.000001267
Score: 0.189
Data Source: BioPlex,STRINGDB
CD300LG
Tbio
Novelty: 0.12664188
Score: 0.576
Data Source: STRINGDB
OR52N5
Tdark
Family: oGPCR
Novelty: 6.7699115
Score: 0.571
Data Source: STRINGDB
TEX30
Tdark
Novelty: 0.69754742
Score: 0.544
Data Source: STRINGDB
LDAH
Tbio
Family: Enzyme
Novelty: 0.0951829
Score: 0.529
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.25

PubMed score by year
PubTator Score  0.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer