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Tdark
TRABD
TraB domain-containing protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303434
  • ENSP00000305664
  • ENSG00000170638
  • ENST00000380909
  • ENSP00000370295
  • ENST00000395827
  • ENSP00000379171

Symbol
  • TTG2
  • LP6054
  • PP2447
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.83
transcription factor perturbation
0.8
histone modification site profile
0.7
tissue sample
0.69
cellular component
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 52   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 52   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3
4
97.7
platelet crit
2
3
4
97.7
hematological measurement
1
1
1
80.4
mitochondrial DNA measurement
1
2
2
76.1
eosinophil count
2
1
2
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
97.7
platelet crit
4
97.7
hematological measurement
1
80.4
mitochondrial DNA measurement
2
76.1
eosinophil count
2
68.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TraB domain containing
VGNC:5985
458931
Macaque
TraB domain containing
715553
Mouse
MGI:1915226
67976
Rat
RGD:1310875
300142
Dog
TraB domain containing
VGNC:47760
607061
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TraB domain containing
Macaque
TraB domain containing
Mouse
Rat
Dog
TraB domain containing
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4I3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (32)
1 – 10 of 32
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.999099244
p_ni:  0.000898499
p_wrong:  0.000002257
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.994460075
p_ni:  0.005539897
p_wrong:  2.7e-8
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.94167099
p_ni:  0.05832901
Score:  0.152
Data Source:  BioPlex,STRINGDB
DNAJC11
Tbio
Novelty:  0.31080011
p_int:  0.939075803
p_ni:  0.060924196
Score:  0.188
Data Source:  BioPlex,STRINGDB
HSDL1
Tbio
Family:  Enzyme
Novelty:  0.24066595
p_int:  0.93065388
p_ni:  0.06934612
Score:  0.185
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.90568753
p_ni:  0.094312424
p_wrong:  4.6e-8
Score:  0.163
Data Source:  BioPlex,STRINGDB
FCN1
Tbio
Novelty:  0.01037775
p_int:  0.894042841
p_ni:  0.105760088
p_wrong:  0.000197071
Score:  0.187
Data Source:  BioPlex,STRINGDB
TRABD2B
Tbio
Family:  Enzyme
Novelty:  0.12802951
Score:  0.738
Data Source:  STRINGDB
TRABD2A
Tbio
Family:  Enzyme
Novelty:  0.23707192
Score:  0.73
Data Source:  STRINGDB
PANX2
Tbio
Family:  IC
Novelty:  0.00620748
Score:  0.608
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.17

PubMed score by year
PubTator Score  0.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer