ZHX3
Zinc fingers and homeoboxes protein 3
Protein Summary
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
- ENST00000309060
- ENSP00000312222
- ENSG00000174306
- ENST00000432768
- ENSP00000415498
- ENST00000544979
- ENSP00000443783
- ENST00000559234
- ENSP00000452965
- ENST00000560361
- ENSP00000454006
- KIAA0395
- TIX1
- TIX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.97 | ||
cell type or tissue | 0.73 | ||
tissue sample | 0.72 | ||
molecular function | 0.7 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.08 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.08 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0