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Tbio
ZHX3
Zinc fingers and homeoboxes protein 3

Protein Classes
Protein Summary
Description
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309060
  • ENSP00000312222
  • ENSG00000174306
  • ENST00000432768
  • ENSP00000415498
  • ENST00000544979
  • ENSP00000443783
  • ENST00000559234
  • ENSP00000452965
  • ENST00000560361
  • ENSP00000454006

Symbol
  • KIAA0395
  • TIX1
  • TIX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
cell type or tissue
0.73
tissue sample
0.72
molecular function
0.7
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.31   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.31   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
3
4
6
94
heel bone mineral density
2
1
2
92.4
balding measurement
1
1
1
92.3
sex hormone-binding globulin measurement
2
1
2
85.1
low density lipoprotein cholesterol measurement
2
3
5
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
6
94
heel bone mineral density
2
92.4
balding measurement
1
92.3
sex hormone-binding globulin measurement
2
85.1
low density lipoprotein cholesterol measurement
5
79.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc fingers and homeoboxes 3
696707
Mouse
MGI:2444772
320799
Rat
RGD:631431
311604
Dog
zinc fingers and homeoboxes 3
VGNC:48633
485875
Cow
zinc fingers and homeoboxes 3
VGNC:37184
512451
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc fingers and homeoboxes 3
Mouse
Rat
Dog
zinc fingers and homeoboxes 3
Cow
zinc fingers and homeoboxes 3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H4I2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (17)
1 – 10 of 17
WDYHV1
Tbio
Family: Enzyme
Novelty: 0.1844203
p_int: 0.999474255
p_ni: 0.000525745
Score: 0.189
Data Source: BioPlex,STRINGDB
PDIA6
Tchem
Family: Enzyme
Novelty: 0.01692178
p_int: 0.759096115
p_ni: 0.240696156
p_wrong: 0.000207729
Score: 0.519
Data Source: BioPlex,STRINGDB
NFYA
Tbio
Family: TF
Novelty: 0.00507094
Score: 0.829
Data Source: STRINGDB
NLK
Tchem
Family: Kinase
Novelty: 0.01512201
Score: 0.65
Data Source: STRINGDB
MCTS1
Tbio
Novelty: 0.07039427
Score: 0.533
Data Source: STRINGDB
ALG8
Tbio
Family: Enzyme
Novelty: 0.03721075
Score: 0.522
Data Source: STRINGDB
EIF3H
Tbio
Novelty: 0.02564681
Score: 0.497
Data Source: STRINGDB
VSIG10
Tdark
Novelty: 1.61084351
Score: 0.496
Data Source: STRINGDB
PCBP2
Tbio
Novelty: 0.00826649
Score: 0.467
Data Source: STRINGDB
ZHX2
Tbio
Family: TF
Novelty: 0.01370086
Score: 0.466
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.31

PubMed score by year
PubTator Score  2.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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