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Tbio
SMOC1
SPARC-related modular calcium-binding protein 1

Protein Summary
Description
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation. This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361956
  • ENSP00000355110
  • ENSG00000198732
  • ENST00000381280
  • ENSP00000370680

Symbol
  • OAS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.76
trait
0.75
protein domain
0.73
transcription factor
0.65
cell line
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.94   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.94   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
2
4
86.9
digit length ratio
3
1
4
84.3
appendicular lean mass
1
1
1
82.5
mean corpuscular hemoglobin concentration
1
1
1
80
heel bone mineral density
2
2
2
73
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
86.9
digit length ratio
4
84.3
appendicular lean mass
1
82.5
mean corpuscular hemoglobin concentration
1
80
heel bone mineral density
2
73
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (65)
1 – 10 of 65
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.999553178
p_ni: 0.000446821
p_wrong: 1e-9
Data Source: BioPlex
NME2
Tbio
Family: Kinase
Novelty: 0.00257937
p_int: 0.999204369
p_ni: 0.000795629
p_wrong: 2e-9
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.999065582
p_ni: 0.000934418
Score: 0.216
Data Source: BioPlex,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.998727128
p_ni: 0.001272515
p_wrong: 3.57e-7
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.998454363
p_ni: 0.001545637
p_wrong: 1e-9
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.995938779
p_ni: 0.003983455
p_wrong: 0.000077767
Score: 0.175
Data Source: BioPlex,STRINGDB
PRSS21
Tbio
Family: Enzyme
Novelty: 0.0110251
p_int: 0.994388337
p_ni: 0.005528486
p_wrong: 0.000083178
Data Source: BioPlex
RETNLB
Tbio
Novelty: 0.00777842
p_int: 0.988126839
p_ni: 0.011652154
p_wrong: 0.000221007
Data Source: BioPlex
TCTN1
Tbio
Novelty: 0.0657704
p_int: 0.979389
p_ni: 0.019378685
p_wrong: 0.001232315
Data Source: BioPlex
NAF1
Tbio
Novelty: 2.99493689
p_int: 0.973761616
p_ni: 0.026120812
p_wrong: 0.000117573
Score: 0.177
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  34.94

PubMed score by year
PubTator Score  102.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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