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Tbio
DEF6
Differentially expressed in FDCP 6 homolog

Protein Classes
Protein Summary
Description
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling (By similarity). DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316637
  • ENSP00000319831
  • ENSG00000023892

Symbol
  • IBP
  • IBP
  • SLAT
  • SWAP70L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
transcription factor
0.72
kinase perturbation
0.71
tissue sample
0.69
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.73   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.73   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
7
9
95.1
body height
6
5
7
94.9
lymphocyte count
2
2
2
87.4
heel bone mineral density
2
2
3
79.3
leukocyte count
1
1
1
78.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
9
95.1
body height
7
94.9
lymphocyte count
2
87.4
heel bone mineral density
3
79.3
leukocyte count
1
78.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEF6, guanine nucleotide exchange factor
VGNC:2683
462636
Macaque
DEF6, guanine nucleotide exchange factor
718845
Mouse
MGI:1346328
23853
Rat
RGD:1307945
309642
Dog
DEF6, guanine nucleotide exchange factor
VGNC:39874
608163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEF6, guanine nucleotide exchange factor
Macaque
DEF6, guanine nucleotide exchange factor
Mouse
Rat
Dog
DEF6, guanine nucleotide exchange factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4E7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of RAC1 activity
PathwayCommons: netpath
TCR
PathwayCommons: pid
Regulation of RhoA activity
Name
Explore in Pharos
Explore in Source
Regulation of RAC1 activity
TCR
Regulation of RhoA activity
Gene Ontology Terms (9)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (36)
1 – 10 of 36
ARHGAP42
Tbio
Family:  Enzyme
Novelty:  0.19934281
p_int:  0.999999919
p_ni:  5.3e-8
p_wrong:  2.8e-8
Score:  0.288
Data Source:  BioPlex,STRINGDB
GRID1
Tbio
Family:  IC
Novelty:  0.05041468
p_int:  0.99999479
p_ni:  0.00000521
Score:  0.288
Data Source:  BioPlex,STRINGDB
ABRAXAS2
Tbio
Novelty:  0.20430604
p_int:  0.999990887
p_ni:  0.000009113
Score:  0.53
Data Source:  BioPlex,STRINGDB
HOMEZ
Tdark
Family:  TF
Novelty:  0.21405573
p_int:  0.999969263
p_ni:  0.000030729
p_wrong:  8e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
BABAM2
Tbio
Novelty:  0.00448485
p_int:  0.999926392
p_ni:  0.000073608
Score:  0.692
Data Source:  BioPlex,STRINGDB
PRKCQ
Tchem
Family:  Kinase
Novelty:  0.00562719
p_int:  0.999904391
p_ni:  0.000095608
Score:  0.305
Data Source:  BioPlex,STRINGDB
RBM45
Tbio
Novelty:  0.06739873
p_int:  0.999862082
p_ni:  0.000137712
p_wrong:  2.06e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
BABAM1
Tbio
Novelty:  0.03812501
p_int:  0.999749468
p_ni:  0.000250532
Score:  0.692
Data Source:  BioPlex,STRINGDB
ANKS1A
Tbio
Novelty:  0.01972212
p_int:  0.999670842
p_ni:  0.000329062
p_wrong:  9.6e-8
Score:  0.288
Data Source:  BioPlex,STRINGDB
NFKB2
Tchem
Family:  TF
Novelty:  0.00366074
p_int:  0.998590833
p_ni:  0.001409167
Score:  0.215
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.73

PubMed score by year
PubTator Score  85.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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