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Tbio
RHOJ
Rho-related GTP-binding protein RhoJ

Protein Summary
Description
Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316754
  • ENSP00000316729
  • ENSG00000126785

Symbol
  • ARHJ
  • RASL7B
  • RHOI
  • TCL
  • TCL
  • ARHJ
  • TC10B
  • RASL7B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
virus perturbation
0.83
small molecule perturbation
0.77
disease perturbation
0.68
gene perturbation
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.84   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
26.1
1
1
0
3.1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
26.1
0
3.1
15.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member J
VGNC:3339
452960
Macaque
ras homolog family member J
705603
Mouse
MGI:1931551
80837
Rat
RGD:1310528
299145
Dog
ras homolog family member J
VGNC:45562
612985
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras homolog family member J
Macaque
ras homolog family member J
Mouse
Rat
Dog
ras homolog family member J
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4E5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (67)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (228)
1 – 10 of 228
PARD6B
Tbio
Novelty:  0.08495161
p_int:  0.99943962
p_ni:  0.000548341
p_wrong:  0.000012039
Score:  0.725
Data Source:  BioPlex,STRINGDB
PARD6G
Tbio
Novelty:  0.23553331
p_int:  0.999235926
p_ni:  0.000013858
p_wrong:  0.000750217
Score:  0.526
Data Source:  BioPlex,STRINGDB
USP24
Tbio
Family:  Enzyme
Novelty:  0.07281326
p_int:  0.998389519
p_ni:  0.00161048
p_wrong:  1e-9
Score:  0.254
Data Source:  BioPlex,STRINGDB
FAM177A1
Tdark
Novelty:  0.31314275
p_int:  0.99719946
p_ni:  0.002800539
Score:  0.179
Data Source:  BioPlex,STRINGDB
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
p_int:  0.986382572
p_ni:  0.013326543
p_wrong:  0.000290885
Score:  0.69
Data Source:  BioPlex,STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.983996276
p_ni:  0.016003659
p_wrong:  6.5e-8
Score:  0.863
Data Source:  BioPlex,STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
p_int:  0.954331882
p_ni:  0.045588949
p_wrong:  0.000079169
Score:  0.566
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.820740668
p_ni:  0.122945984
p_wrong:  0.056313349
Score:  0.209
Data Source:  BioPlex,STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.966
Data Source:  STRINGDB
MCF2
Tbio
Novelty:  0.00345951
Score:  0.966
Data Source:  STRINGDB
Publication Statistics
PubMed Score  76.84

PubMed score by year
PubTator Score  82.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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