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Tclin
TUBB1
Tubulin beta-1 chain

Protein Summary
Description
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217133
  • ENSP00000217133
  • ENSG00000101162
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
0.97
molecular function
0.93
cell type or tissue
0.85
drug
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.2   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.2   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
5
7
32.8
96.4
mean platelet volume
3
4
6
93
red blood cell density measurement
1
1
1
73
platelet crit
1
2
2
69.7
hemoglobin measurement
1
1
1
55.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
7
32.8
96.4
mean platelet volume
6
93
red blood cell density measurement
1
73
platelet crit
2
69.7
hemoglobin measurement
1
55.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 1 class VI
VGNC:10060
736308
Macaque
tubulin beta 1 class VI
693889
Mouse
MGI:107814
545486
Rat
RGD:1589557
679312
Dog
tubulin beta 1 class VI
VGNC:49697
485950
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulin beta 1 class VI
Macaque
tubulin beta 1 class VI
Mouse
Rat
Dog
tubulin beta 1 class VI
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H4B7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (48)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Formation of tubulin folding intermediates by CCT/TriC
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Formation of tubulin folding intermediates by CCT/TriC
Metabolism of proteins
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (145)
1 – 10 of 145
CAPS
Tbio
Novelty: 0.04549022
p_int: 0.999999837
p_ni: 1.63e-7
Data Source: BioPlex
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.999996093
p_ni: 0.000003907
Score: 0.207
Data Source: BioPlex,STRINGDB
TSPYL6
Tdark
Novelty: 0.68478376
p_int: 0.999995759
p_ni: 0.000004239
p_wrong: 2e-9
Data Source: BioPlex
MUC20
Tbio
Novelty: 0.04645313
p_int: 0.999994307
p_ni: 0.000005693
Data Source: BioPlex
DOCK5
Tbio
Novelty: 0.03153692
p_int: 0.999993427
p_ni: 0.000006572
Data Source: BioPlex
WNT7A
Tbio
Novelty: 0.00421662
p_int: 0.999992548
p_ni: 0.000007452
Data Source: BioPlex
CLEC4C
Tbio
Novelty: 0.00845053
p_int: 0.999991757
p_ni: 0.000008242
Data Source: BioPlex
PRSS2
Tchem
Family: Enzyme
Novelty: 0.00959404
p_int: 0.999988292
p_ni: 0.000011707
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.999981933
p_ni: 0.000018067
Data Source: BioPlex
ENPP7
Tbio
Family: Enzyme
Novelty: 0.01963359
p_int: 0.999981271
p_ni: 0.000018728
Score: 0.152
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  32.20

PubMed score by year
PubTator Score  16.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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