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Tchem
PLK3
Serine/threonine-protein kinase PLK3

Protein Summary
Description
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372201
  • ENSP00000361275
  • ENSG00000173846

Symbol
  • CNK
  • FNK
  • PRK
  • CNK
  • FNK
  • PRK
  • PLK-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
molecular function
0.93
protein domain
0.92
transcription factor binding site profile
0.89
gene perturbation
0.88


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.33   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 148.33   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 3
VGNC:6956
456546
Macaque
polo like kinase 3
704071
Mouse
MGI:109604
12795
Rat
RGD:62039
58936
Dog
polo like kinase 3
VGNC:44697
475380
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 3
Macaque
polo like kinase 3
Mouse
Rat
Dog
polo like kinase 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H4B4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Phosphorylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Phosphorylation
Gene Ontology Terms (34)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (154)
1 – 10 of 154
CDC25C
Tchem
Family: Enzyme
Novelty: 0.00227769
Score: 0.985
Data Source: Reactome,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.979
Data Source: Reactome,STRINGDB
CHEK2
Tchem
Family: Kinase
Novelty: 0.00068355
Score: 0.975
Data Source: STRINGDB
ATM
Tchem
Family: Kinase
Novelty: 0.00019169
Score: 0.956
Data Source: STRINGDB
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
Score: 0.922
Data Source: STRINGDB
RASGRF1
Tbio
Novelty: 0.0093175
Score: 0.908
Data Source: STRINGDB
TP73
Tbio
Family: TF
Novelty: 0.00667737
Score: 0.905
Data Source: STRINGDB
YWHAH
Tchem
Novelty: 0.01000071
Score: 0.901
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.842
Data Source: STRINGDB
MAD2L1
Tbio
Novelty: 0.01623659
Score: 0.84
Data Source: STRINGDB
Publication Statistics
PubMed Score  148.33

PubMed score by year
PubTator Score  137.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer