Tbio GOLPH3 Golgi phosphoprotein 3

Protein Summary

Description

Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through interaction with their cytoplasmic part. May play an indirect role in cell migration. Has also been involved in the modulation of mTOR signaling. May also be involved in the regulation of mitochondrial lipids biosynthesis. The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H4A6
• Q9UIW5

Gene Name

• GOLPH3

Ensembl ID

• ENST00000265070
• ENSP00000265070
• ENSG00000113384

Symbol

• GPP34
• GOPP1
• GPP34
• MIDAS
• Vps74

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.86
interacting protein	0.86
transcription factor binding site profile	0.86
disease perturbation	0.83
tissue sample	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5157.84   (req: < 5)

Gene RIFs: 99   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5157.84   (req: >= 5)

Gene RIFs: 99   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0