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Tchem
RNPEP
Aminopeptidase B

Protein Summary
Description
Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295640
  • ENSP00000295640
  • ENSG00000176393

Symbol
  • APB
  • APB
  • AP-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
disease perturbation
0.93
virus perturbation
0.76
transcription factor binding site profile
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.93   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.93   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (82)
1 – 10 of 82
FAM98B
Tdark
Novelty:  0.47641513
Score:  0.873
Data Source:  STRINGDB
TRIM25
Tbio
Family:  Enzyme
Novelty:  0.0045864
Score:  0.827
Data Source:  STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.809
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.797
Data Source:  STRINGDB
STIM1
Tbio
Novelty:  0.00116516
Score:  0.797
Data Source:  STRINGDB
ORAI1
Tchem
Family:  IC
Novelty:  0.00179685
Score:  0.76
Data Source:  STRINGDB
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
Score:  0.752
Data Source:  STRINGDB
TRPC1
Tbio
Family:  IC
Novelty:  0.00233677
Score:  0.747
Data Source:  STRINGDB
GRM6
Tchem
Family:  GPCR
Novelty:  0.00681104
Score:  0.739
Data Source:  STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.73
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
2
2
1
1.1
91.9
body mass index
4
2
6
91.2
butyrylcholinesterase measurement
1
1
1
65.3
2
2
2
63.7
depressive symptom measurement
4
2
4
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1.1
91.9
body mass index
6
91.2
butyrylcholinesterase measurement
1
65.3
2
63.7
depressive symptom measurement
4
58.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginyl aminopeptidase
VGNC:6986
469638
Macaque
arginyl aminopeptidase
706696
Mouse
MGI:2384902
215615
Rat
RGD:621137
81761
Dog
arginyl aminopeptidase
VGNC:45682
490236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginyl aminopeptidase
Macaque
arginyl aminopeptidase
Mouse
Rat
Dog
arginyl aminopeptidase
Publication Statistics
PubMed Score 262.93
PubMed score by year
PubTator Score 136.99
PubTator score by year